NRAS G13D
Gene Variant Detail

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Gene NRAS
Variant G13D
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions NRAS G13D is a hotspot mutation that lies within a GTP-binding region of the Nras protein (UniProt.org). G13D confers a loss of function on Nras protein as indicated by increased GTP-bound Nras, which leads to activation of downstream pathway signaling in cell culture (PMID: 17517660).
Associated Drug Resistance
Category Variants Paths

NRAS mutant NRAS act mut NRAS G13D

NRAS mutant NRAS exon2 NRAS G13X NRAS G13D

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Transcript NM_002524.5
gDNA chr1:g.114716123C>T
cDNA c.38G>A
Protein p.G13D
Source Database RefSeq
Genome Build GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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