NRAS G13D
Gene Variant Detail

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Gene NRAS
Variant G13D
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions NRAS G13D is a hotspot mutation that lies within a GTP-binding region of the Nras protein (UniProt.org). G13D confers a loss of function on Nras protein as indicated by increased GTP-bound Nras, which leads to activation of downstream pathway signaling in cell culture (PMID: 17517660).
Associated Drug Resistance
Category Variants Paths

NRAS mutant NRAS act mut NRAS G13D

NRAS mutant NRAS exon2 NRAS G13X NRAS G13D

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Transcript NM_002524.5
gDNA chr1:g.114716123C>T
cDNA c.38G>A
Protein p.G13D
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002524.4 chr1:g.114716123C>T c.38G>A p.G13D RefSeq GRCh38/hg38
NM_002524.5 chr1:g.114716123C>T c.38G>A p.G13D RefSeq GRCh38/hg38
NM_002524 chr1:g.114716123C>T c.38G>A p.G13D RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Protein Effect Treatment Approaches
NRAS G13D loss of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan)
FLT3 exon 14 ins FLT3 D835X NRAS G13D