Gene Variant Detail

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Gene NRAS
Variant G13R
Impact List missense
Protein Effect loss of function - predicted
Gene Variant Descriptions NRAS G13R is a hotspot mutation that lies within a GTP-binding region of the Nras protein (UniProt.org). G13R results in increased MAPK/ERK pathway activation in an in vitro assay, is transforming in culture (PMID: 34117033), and can be predicted to lead to a loss of Nras protein function based on the effects of other NRAS G13 mutations.
Associated Drug Resistance
Category Variants Paths

NRAS mutant NRAS act mut NRAS G13R

NRAS mutant NRAS exon2 NRAS G13X NRAS G13R

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Transcript NM_002524.5
gDNA chr1:g.114716124C>G
cDNA c.37G>C
Protein p.G13R
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002524 chr1:g.114716124C>G c.37G>C p.G13R RefSeq GRCh38/hg38
NM_002524.4 chr1:g.114716124C>G c.37G>C p.G13R RefSeq GRCh38/hg38
NM_002524.5 chr1:g.114716124C>G c.37G>C p.G13R RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries