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Gene NRAS
Variant G13V
Impact List missense
Protein Effect loss of function - predicted
Gene Variant Descriptions NRAS G13V is a hotspot mutation that lies within a GTP-binding region of the Nras protein (UniProt.org). G13V has not been characterized, but can be predicted to confer a loss of function to the Nras protein based on the effects of HRAS G13V, which results in a loss of response to GTPase-activating proteins, leading to increased GTP-bound Hras in culture (PMID: 24224811).
Associated Drug Resistance
Category Variants Paths

NRAS mutant NRAS act mut NRAS G13V

NRAS mutant NRAS exon2 NRAS G13X NRAS G13V

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Transcript NM_002524.5
gDNA chr1:g.114716123C>A
cDNA c.38G>T
Protein p.G13V
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002524.4 chr1:g.114716123C>A c.38G>T p.G13V RefSeq GRCh38/hg38
NM_002524 chr1:g.114716123C>A c.38G>T p.G13V RefSeq GRCh38/hg38
NM_002524.5 chr1:g.114716123C>A c.38G>T p.G13V RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries