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Gene NRAS
Variant G13V
Impact List missense
Protein Effect loss of function - predicted
Gene Variant Descriptions NRAS G13V is a hotspot mutation that lies within a GTP-binding region of the Nras protein (UniProt.org). G13V has not been characterized, but can be predicted to confer a loss of function to the Nras protein based on the effects of HRAS G13V, which results in a loss of response to GTPase-activating proteins, leading to increased GTP-bound Hras in culture (PMID: 24224811).
Associated Drug Resistance
Category Variants Paths

NRAS mutant NRAS act mut NRAS G13V

NRAS mutant NRAS exon2 NRAS G13X NRAS G13V

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Transcript NM_002524.5
gDNA chr1:g.114716123C>A
cDNA c.38G>T
Protein p.G13V
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002524 chr1:g.114716123C>A c.38G>T p.G13V RefSeq GRCh38/hg38
NM_002524.4 chr1:g.114716123C>A c.38G>T p.G13V RefSeq GRCh38/hg38
NM_002524.5 chr1:g.114716123C>A c.38G>T p.G13V RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
NRAS G13V adult T-cell leukemia/lymphoma sensitive 3144 Preclinical - Pdx & cell culture Actionable In a preclinical study, 3144 inhibited growth of patient-derived T-cell acute lymphocytic leukemia cells harboring NRAS G13V in culture, and reduced tumor burden in xenograft models (PMID: 28235199). 28235199