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Gene NRAS
Variant G13C
Impact List missense
Protein Effect loss of function - predicted
Gene Variant Descriptions NRAS G13C is a hotspot mutation that lies within a GTP-binding region of the Nras protein (UniProt.org). G13C has not been characterized, but can be predicted to confer a loss of function to the Nras protein based on the effects of KRAS G13C and HRAS G13C, which result in increased GTP-bound Ras and activation of downstream signaling (PMID: 25705018, PMID: 21850009).
Associated Drug Resistance
Category Variants Paths

NRAS mutant NRAS act mut NRAS G13C

NRAS mutant NRAS exon2 NRAS G13X NRAS G13C

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Transcript NM_002524.5
gDNA chr1:g.114716124C>A
cDNA c.37G>T
Protein p.G13C
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002524.4 chr1:g.114716124C>A c.37G>T p.G13C RefSeq GRCh38/hg38
NM_002524.5 chr1:g.114716124C>A c.37G>T p.G13C RefSeq GRCh38/hg38
NM_002524 chr1:g.114716124C>A c.37G>T p.G13C RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Protein Effect Treatment Approaches
NRAS G13C loss of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan)
FLT3 exon 14 ins FLT3 D835X NRAS G13C NRAS G13R