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Gene APC
Variant T1556Nfs*3
Impact List frameshift
Protein Effect loss of function
Gene Variant Descriptions APC T1556Nfs*3 indicates a shift in the reading frame starting at amino acid 1556 and terminating 3 residues downstream causing a premature truncation of the 2843 amino acid Apc protein (UniProt.org). T1556Nfs*3 retains binding with Axin1 but confers a loss of function to Apc as demonstrated by decreased beta-catenin recruitment, phosphorylation, and ubiquitination in cultured cells (PMID: 34352208).
Associated Drug Resistance
Category Variants Paths

APC mutant APC inact mut APC T1556fs APC T1556Nfs*3

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Transcript NM_000038.6
gDNA chr5:g.112840260dupA
cDNA c.4666dupA
Protein p.T1556Nfs*3
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001127510 chr5:g.112840258_112840259insG c.4664_4665insG p.T1556Nfs*3 RefSeq GRCh38/hg38
NM_001354902.2 chr5:g.112840534delC c.4667delC p.T1556Nfs*3 RefSeq GRCh38/hg38
NM_001407450.1 chr5:g.112840260dupA c.4666dupA p.T1556Nfs*3 RefSeq GRCh38/hg38
NM_000038.5 chr5:g.112840260dupA c.4666dupA p.T1556Nfs*3 RefSeq GRCh38/hg38
NM_001354900.2 chr5:g.112840383_112840384insACCCCTAA c.4666_4667insACCCCTAA p.T1556Nfs*3 RefSeq GRCh38/hg38
NM_001127510.2 chr5:g.112840260dupA c.4666dupA p.T1556Nfs*3 RefSeq GRCh38/hg38
NM_001127510.3 chr5:g.112840260dupA c.4666dupA p.T1556Nfs*3 RefSeq GRCh38/hg38
NM_000038 chr5:g.112840258_112840259insG c.4664_4665insG p.T1556Nfs*3 RefSeq GRCh38/hg38
NM_001354895.1 chr5:g.112840260dupA c.4666dupA p.T1556Nfs*3 RefSeq GRCh38/hg38
NM_000038.6 chr5:g.112840260dupA c.4666dupA p.T1556Nfs*3 RefSeq GRCh38/hg38
NM_001354895.2 chr5:g.112840260dupA c.4666dupA p.T1556Nfs*3 RefSeq GRCh38/hg38

Filtering

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Protein Effect Treatment Approaches
APC T1556Nfs*3 loss of function CTNNB1 Inhibitor Tankyrase Inhibitor
APC E853* APC T1556Nfs*3
APC V830Gfs*12 APC T1556Nfs*3
APC S1465Wfs*3 APC T1556Nfs*3