NRAS G13A - Gene Variant Detail

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Gene NRAS
Variant G13A
Impact List missense
Protein Effect unknown
Gene Variant Descriptions NRAS G13A is a hotspot mutation that lies within a GTP-binding region of the Nras protein (UniProt.org). G13A has been identified in the scientific literature (PMID: 22589270) but has not been biochemically characterized and therefore, its effect on Nras protein function is unknown (PubMed, Dec 2024).
Associated Drug Resistance
Category Variants Paths

NRAS mutant NRAS exon2 NRAS G13X NRAS G13A

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Transcript NM_002524.5
gDNA chr1:g.114716123C>G
cDNA c.38G>C
Protein p.G13A
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002524 chr1:g.114716123C>G c.38G>C p.G13A RefSeq GRCh38/hg38
NM_002524.4 chr1:g.114716123C>G c.38G>C p.G13A RefSeq GRCh38/hg38
NM_002524.5 chr1:g.114716123C>G c.38G>C p.G13A RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References