NRAS Q61E
Gene Variant Detail

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Gene NRAS
Variant Q61E
Impact List missense
Protein Effect unknown
Gene Variant Descriptions NRAS Q61E is a hotspot mutation that lies within a GTP-binding region of the Nras protein (UniProt.org). Q61E results in an intermediate change of Erk2 translocation in culture (PMID: 34117033), but has not been fully biochemically characterized and therefore, its effect on Nras protein function is unknown.
Associated Drug Resistance
Category Variants Paths

NRAS mutant NRAS exon3 NRAS Q61X NRAS Q61E

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Transcript NM_002524.5
gDNA chr1:g.114713909G>C
cDNA c.181C>G
Protein p.Q61E
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002524 chr1:g.114713909G>C c.181C>G p.Q61E RefSeq GRCh38/hg38
NM_002524.4 chr1:g.114713909G>C c.181C>G p.Q61E RefSeq GRCh38/hg38
NM_002524.5 chr1:g.114713909G>C c.181C>G p.Q61E RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References