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Gene NRAS
Variant Q61E
Impact List missense
Protein Effect loss of function - predicted
Gene Variant Descriptions NRAS Q61E is a hotspot mutation that lies within a GTP-binding region of the Nras protein (UniProt.org). Q61E has not been characterized, but can be predicted to confer a loss of function to the Nras protein leading to activation of downstream signaling based on the effect of HRAS Q61E, which results in decreased GTPase activity and cell transformation in culture (PMID: 3510078).
Associated Drug Resistance
Category Variants Paths

NRAS mutant NRAS act mut NRAS Q61E

NRAS mutant NRAS exon3 NRAS Q61X NRAS Q61E

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Transcript NM_002524.5
gDNA chr1:g.114713909G>C
cDNA c.181C>G
Protein p.Q61E
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002524 chr1:g.114713909G>C c.181C>G p.Q61E RefSeq GRCh38/hg38
NM_002524.4 chr1:g.114713909G>C c.181C>G p.Q61E RefSeq GRCh38/hg38
NM_002524.5 chr1:g.114713909G>C c.181C>G p.Q61E RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries