NRAS Q61H - Gene Variant Detail

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Gene NRAS
Variant Q61H
Impact List missense
Protein Effect loss of function - predicted
Gene Variant Descriptions NRAS Q61H is a hotspot mutation that lies within a GTP-binding region of the Nras protein (UniProt.org). Q61H results in increased GTP-bound Nras, downstream pathway activation, and increased cell proliferation in culture (PMID: 23103856), and is predicted to lead to a loss of Nras protein function based on the effects of HRAS Q61H (PMID: 3510078) and KRAS Q61H (PMID: 20147967).
Associated Drug Resistance
Category Variants Paths

NRAS mutant NRAS act mut NRAS Q61H

NRAS mutant NRAS exon3 NRAS Q61X NRAS Q61H

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Transcript NM_002524.5
gDNA chr1:g.114713907T>A
cDNA c.183A>T
Protein p.Q61H
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002524 chr1:g.114713907T>A c.183A>T p.Q61H RefSeq GRCh38/hg38
NM_002524.4 chr1:g.114713907T>A c.183A>T p.Q61H RefSeq GRCh38/hg38
NM_002524.5 chr1:g.114713907T>A c.183A>T p.Q61H RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Molecular Profile Protein Effect Treatment Approaches
NRAS Q61H loss of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan)
NRAS Q61H PTEN over exp
FLT3 exon 14 ins FLT3 D835X NRAS Q61H
BRAF V600E NRAS Q61H