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Gene NRAS
Variant Q61L
Impact List missense
Protein Effect loss of function - predicted
Gene Variant Descriptions NRAS Q61L is a hotspot mutation that lies within a GTP-binding region of the Nras protein (UniProt.org). Q61L results in increase Erk and Mek phosphorylation, and activation of Ck2alpha in cell culture (PMID: 27251789), and is predicted to lead to a loss of Nras protein function based on the effects of HRAS Q61L (PMID: 23487764) and KRAS Q61L (PMID: 26037647).
Associated Drug Resistance
Category Variants Paths

NRAS mutant NRAS act mut NRAS Q61L

NRAS mutant NRAS exon3 NRAS Q61X NRAS Q61L

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Transcript NM_002524.5
gDNA chr1:g.114713908T>A
cDNA c.182A>T
Protein p.Q61L
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002524.4 chr1:g.114713908T>A c.182A>T p.Q61L RefSeq GRCh38/hg38
NM_002524 chr1:g.114713908T>A c.182A>T p.Q61L RefSeq GRCh38/hg38
NM_002524.5 chr1:g.114713908T>A c.182A>T p.Q61L RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries