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Gene APC
Variant D1636fs
Impact List frameshift
Protein Effect unknown
Gene Variant Descriptions APC D1636fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1636 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). D1636fs has been identified in sequencing studies (PMID: 36013219), but has not been biochemically characterized and therefore, its effect on Apc protein function is unknown (PubMed, Aug 2024).
Associated Drug Resistance
Category Variants Paths

APC mutant APC D1636fs

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Transcript NM_000038.6
gDNA chr5:g.(112840499_112840500)
cDNA c.(4906_4905)
Protein p.D1636fs
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001354895.2 chr5:g.(112840499_112840500) c.(4906_4905) p.D1636fs RefSeq GRCh38/hg38
NM_001407450.1 chr5:g.(112840499_112840500) c.(4906_4905) p.D1636fs RefSeq GRCh38/hg38
NM_001354895.1 chr5:g.(112840499_112840500) c.(4906_4905) p.D1636fs RefSeq GRCh38/hg38
NM_001127510.3 chr5:g.(112840499_112840500) c.(4906_4905) p.D1636fs RefSeq GRCh38/hg38
NM_000038 chr5:g.(112840499_112840500) c.(4906_4905) p.D1636fs RefSeq GRCh38/hg38
NM_001127510 chr5:g.(112840499_112840500) c.(4906_4905) p.D1636fs RefSeq GRCh38/hg38
NM_000038.6 chr5:g.(112840499_112840500) c.(4906_4905) p.D1636fs RefSeq GRCh38/hg38
NM_000038.5 chr5:g.(112840499_112840500) c.(4906_4905) p.D1636fs RefSeq GRCh38/hg38
NM_001127510.2 chr5:g.(112840499_112840500) c.(4906_4905) p.D1636fs RefSeq GRCh38/hg38

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries