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Gene KIT
Variant V825A
Impact List missense
Protein Effect unknown
Gene Variant Descriptions KIT V825A lies within the protein kinase domain of the Kit protein (UniProt.org). V825A leads to cell growth when combined with the RUNX1-ETO fusion (PMID: 24897507), but has not been characterized individually and therefore, its effect on Kit protein function is unknown (PubMed, Nov 2024).
Associated Drug Resistance
Category Variants Paths

KIT mutant KIT exon17 KIT V825A

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Transcript NM_000222.3
gDNA chr4:g.54733182T>C
cDNA c.2474T>C
Protein p.V825A
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000222.2 chr4:g.54733182T>C c.2474T>C p.V825A RefSeq GRCh38/hg38
NM_001385284.1 chr4:g.54733179T>C c.2474T>C p.V825A RefSeq GRCh38/hg38
XM_005265741 chr4:g.54733182T>C c.2474T>C p.V825A RefSeq GRCh38/hg38
NM_000222.3 chr4:g.54733182T>C c.2474T>C p.V825A RefSeq GRCh38/hg38
XM_005265740 chr4:g.54733179T>C c.2474T>C p.V825A RefSeq GRCh38/hg38
XM_005265741.1 chr4:g.54733182T>C c.2474T>C p.V825A RefSeq GRCh38/hg38
NM_001385290.1 chr4:g.54733182T>C c.2474T>C p.V825A RefSeq GRCh38/hg38
XM_005265740.1 chr4:g.54733179T>C c.2474T>C p.V825A RefSeq GRCh38/hg38
NM_000222 chr4:g.54733182T>C c.2474T>C p.V825A RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
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Molecular Profile Protein Effect Treatment Approaches
KIT V825A unknown KIT Inhibitor