FGFR1 G70R
Gene Variant Detail

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Gene FGFR1
Variant G70R
Impact List missense
Protein Effect unknown
Gene Variant Descriptions FGFR1 G70R lies within Ig-like C2-type domain 1 of the Fgfr1 protein (UniProt.org). G70R results in Erk1/2 phosphorylation similar to wild-type Fgfr1 in cultured cells and Fgfr1 signaling activity similar to wild-type in 1 assay but a modest decrease in another reporter assay (PMID: 32666525), and therefore, its effect on Fgfr1 protein function is unknown.
Associated Drug Resistance
Category Variants Paths

FGFR1 mutant FGFR1 G70R

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Transcript NM_023110.3
gDNA chr8:g.38429832C>T
cDNA c.208G>A
Protein p.G70R
Source Database RefSeq
Genome Build GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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