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Gene | FGFR1 |
Variant | R250W |
Impact List | missense |
Protein Effect | unknown |
Gene Variant Descriptions | FGFR1 R250W lies within the D2-D3 linker region of the Fgfr1 protein (PMID: 23276709). R250W results in similar cell proliferation and viability levels to wild-type Fgfr1 in two different cell lines in culture in one study (PMID: 29533785), decreased proliferation relative to wild-type Fgfr1 in a competition assay, and transformation activity similar to wild-type Fgfr1 in another study (PMID: 34272467), and therefore, its effect on Fgfr1 protein function is unknown. |
Associated Drug Resistance | |
Category Variants Paths |
FGFR1 mutant FGFR1 R250W |
Transcript | NM_023110.3 |
gDNA | chr8:g.38424697G>A |
cDNA | c.748C>T |
Protein | p.R250W |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |