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Gene FGFR1
Variant R646L
Impact List missense
Protein Effect unknown
Gene Variant Descriptions FGFR1 R646L lies within the protein kinase domain of the Fgfr1 protein (UniProt.org). R646L has not been characterized in the scientific literature and therefore, its effect on Fgfr1 protein function is unknown (PubMed, Oct 2024).
Associated Drug Resistance
Category Variants Paths

FGFR1 mutant FGFR1 R646L

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Transcript NM_023110.3
gDNA chr8:g.38414819C>A
cDNA c.1937G>T
Protein p.R646L
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_006716304.2 chr8:g.38414819C>A c.1937G>T p.R646L RefSeq GRCh38/hg38
XM_017013221 chr8:g.38414819C>A c.1937G>T p.R646L RefSeq GRCh38/hg38
NM_023110.2 chr8:g.38414819C>A c.1937G>T p.R646L RefSeq GRCh38/hg38
XM_006716304 chr8:g.38414819C>A c.1937G>T p.R646L RefSeq GRCh38/hg38
XM_006716303.4 chr8:g.38414819C>A c.1937G>T p.R646L RefSeq GRCh38/hg38
XM_017013221.2 chr8:g.38414819C>A c.1937G>T p.R646L RefSeq GRCh38/hg38
NM_023110 chr8:g.38414819C>A c.1937G>T p.R646L RefSeq GRCh38/hg38
XM_006716303.3 chr8:g.38414819C>A c.1937G>T p.R646L RefSeq GRCh38/hg38
NM_023110.3 chr8:g.38414819C>A c.1937G>T p.R646L RefSeq GRCh38/hg38
XM_006716304.1 chr8:g.38414819C>A c.1937G>T p.R646L RefSeq GRCh38/hg38
XM_006716303 chr8:g.38414819C>A c.1937G>T p.R646L RefSeq GRCh38/hg38
XM_017013221.1 chr8:g.38414819C>A c.1937G>T p.R646L RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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  • Click on any column header arrows to sort by that column
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Molecular Profile Protein Effect Treatment Approaches
FGFR1 R646L unknown