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Gene FGFR2
Variant D101Y
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions FGFR2 D101Y lies within the extracellular Ig-like C2-type domain 1 of the Fgfr2 protein (UniProt.org). D101Y results in a growth advantage relative to wild-type Fgfr2 in a competition assay (PMID: 34272467) and increased transformation activity in cultured cells (PMID: 34272467, PMID: 18552176).
Associated Drug Resistance
Category Variants Paths

FGFR2 mutant FGFR2 act mut FGFR2 D101Y

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Transcript NM_000141.5
gDNA chr10:g.121565513C>A
cDNA c.301G>T
Protein p.D101Y
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_022970 chr10:g.121565513C>A c.301G>T p.D101Y RefSeq GRCh38/hg38
NM_000141.5 chr10:g.121565513C>A c.301G>T p.D101Y RefSeq GRCh38/hg38
NM_001144913.1 chr10:g.121565513C>A c.301G>T p.D101Y RefSeq GRCh38/hg38
NM_001144914.1 chr10:g.121565513C>A c.301G>T p.D101Y RefSeq GRCh38/hg38
NM_001144914.1 chr10:g.121565513C>A c.301G>T p.D101Y RefSeq GRCh38/hg38
NM_001320658 chr10:g.121565513C>A c.301G>T p.D101Y RefSeq GRCh38/hg38
NM_001144913.1 chr10:g.121565513C>A c.301G>T p.D101Y RefSeq GRCh38/hg38
NM_022970.4 chr10:g.121565513C>A c.301G>T p.D101Y RefSeq GRCh38/hg38
NM_001320658.2 chr10:g.121565513C>A c.301G>T p.D101Y RefSeq GRCh38/hg38
NM_001144913 chr10:g.121565513C>A c.301G>T p.D101Y RefSeq GRCh38/hg38
NM_001144914 chr10:g.121565513C>A c.301G>T p.D101Y RefSeq GRCh38/hg38
NM_001144917 chr10:g.121565513C>A c.301G>T p.D101Y RefSeq GRCh38/hg38
NM_001144917.1 chr10:g.121565513C>A c.301G>T p.D101Y RefSeq GRCh38/hg38
NM_001320658.1 chr10:g.121565513C>A c.301G>T p.D101Y RefSeq GRCh38/hg38
NM_000141.4 chr10:g.121565513C>A c.301G>T p.D101Y RefSeq GRCh38/hg38
NM_001144917.2 chr10:g.121565513C>A c.301G>T p.D101Y RefSeq GRCh38/hg38
NM_022970.3 chr10:g.121565513C>A c.301G>T p.D101Y RefSeq GRCh38/hg38
NM_000141 chr10:g.121565513C>A c.301G>T p.D101Y RefSeq GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries