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Gene FGFR2
Variant E695K
Impact List missense
Protein Effect loss of function - predicted
Gene Variant Descriptions FGFR2 E695K lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). E695K results in decreased proliferation relative to wild-type Fgfr2 in a competition assay and decreased transformation activity in cultured cells (PMID: 34272467), and therefore, is predicted to lead to a loss of Fgfr2 protein function.
Associated Drug Resistance
Category Variants Paths

FGFR2 mutant FGFR2 inact mut FGFR2 E695K

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Transcript NM_000141.5
gDNA chr10:g.121485507C>T
cDNA c.2083G>A
Protein p.E695K
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000141 chr10:g.121485507C>T c.2083G>A p.E695K RefSeq GRCh38/hg38
NM_000141.4 chr10:g.121485507C>T c.2083G>A p.E695K RefSeq GRCh38/hg38
NM_000141.5 chr10:g.121485507C>T c.2083G>A p.E695K RefSeq GRCh38/hg38
XM_024447889.1 chr10:g.121483700C>T c.2083G>A p.E695K RefSeq GRCh38/hg38
XM_024447889.2 chr10:g.121483700C>T c.2083G>A p.E695K RefSeq GRCh38/hg38
XM_017015923 chr10:g.121483700C>T c.2083G>A p.E695K RefSeq GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References