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Gene TP53
Variant A307fs
Impact List frameshift
Protein Effect loss of function - predicted
Gene Variant Descriptions TP53 A307fs results in a change in the amino acid sequence of the Tp53 protein beginning at aa 307 of 393, likely resulting in premature truncation of the functional protein (UniProt.org). A307fs has not been biochemically characterized however, due to the effects of truncation mutations downstream of A307 (PMID: 31081129, PMID: 34045312), is predicted to lead to a loss of Tp53 protein function.
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon8 TP53 A307fs

TP53 mutant TP53 exon9 TP53 A307fs

TP53 mutant TP53 inact mut TP53 A307fs

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Transcript NM_000546.6
gDNA chr17:g.(7673701_7673702)
cDNA c.(919_918)
Protein p.A307fs
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001407268.1 chr17:g.(7673701_7673702) c.(919_918) p.A307fs RefSeq GRCh38/hg38
NM_001126113.3 chr17:g.(7673701_7673702) c.(919_918) p.A307fs RefSeq GRCh38/hg38
NM_001126114.3 chr17:g.(7673701_7673702) c.(919_918) p.A307fs RefSeq GRCh38/hg38
NM_000546.5 chr17:g.(7673701_7673702) c.(919_918) p.A307fs RefSeq GRCh38/hg38
NM_001126113 chr17:g.(7673701_7673702) c.(919_918) p.A307fs RefSeq GRCh38/hg38
NM_001126114.2 chr17:g.(7673701_7673702) c.(919_918) p.A307fs RefSeq GRCh38/hg38
NM_000546.6 chr17:g.(7673701_7673702) c.(919_918) p.A307fs RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.(7673701_7673702) c.(919_918) p.A307fs RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.(7673701_7673702) c.(919_918) p.A307fs RefSeq GRCh38/hg38
NM_001407264.1 chr17:g.(7673701_7673702) c.(919_918) p.A307fs RefSeq GRCh38/hg38
NM_000546 chr17:g.(7673701_7673702) c.(919_918) p.A307fs RefSeq GRCh38/hg38
NM_001407270.1 chr17:g.(7673701_7673702) c.(919_918) p.A307fs RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.(7673701_7673702) c.(919_918) p.A307fs RefSeq GRCh38/hg38
NM_001126113.2 chr17:g.(7673701_7673702) c.(919_918) p.A307fs RefSeq GRCh38/hg38
NM_001126114 chr17:g.(7673701_7673702) c.(919_918) p.A307fs RefSeq GRCh38/hg38
NM_001126112 chr17:g.(7673701_7673702) c.(919_918) p.A307fs RefSeq GRCh38/hg38
NM_001126112.2 chr17:g.(7673701_7673702) c.(919_918) p.A307fs RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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  • Click on any column header arrows to sort by that column
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Molecular Profile Protein Effect Treatment Approaches
TP53 A307fs loss of function - predicted p53 Gene Therapy