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Gene FGFR2
Variant K660E
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions FGFR2 K660E (corresponds to K659E in the canonical isoform) lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). K660E results in increased phosphorylation of Fgfr2, activation of downstream signaling, and is transforming in cell culture (PMID: 23786770).
Associated Drug Resistance Y
Category Variants Paths

FGFR2 mutant FGFR2 act mut FGFR2 K660E

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Transcript NM_022970.4
gDNA chr10:g.121488002T>C
cDNA c.1978A>G
Protein p.K660E
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_022970.4 chr10:g.121488002T>C c.1978A>G p.K660E RefSeq GRCh38/hg38
NM_022970.3 chr10:g.121488002T>C c.1978A>G p.K660E RefSeq GRCh38/hg38
NM_022970 chr10:g.121488002T>C c.1978A>G p.K660E RefSeq GRCh38/hg38
NM_001144913.1 chr10:g.121488002T>C c.1978A>G p.K660E RefSeq GRCh38/hg38
NM_001144913.1 chr10:g.121488002T>C c.1978A>G p.K660E RefSeq GRCh38/hg38
NM_001144913 chr10:g.121488002T>C c.1978A>G p.K660E RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Protein Effect Treatment Approaches
FGFR2 K660E gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor