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Gene TP53
Variant S215R
Impact List missense
Protein Effect unknown
Gene Variant Descriptions TP53 S215R lies within the DNA-binding domain of the Tp53 protein (PMID: 15510160). S215R is predicted to result in a constitutively active S6-S7 loop by structural modeling (PMID: 35659507), but has not been biochemically characterized and therefore, its effect on Tp53 protein function is unknown (PubMed, Sep 2023).
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon6 TP53 S215R

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Transcript NM_000546.6
gDNA chr17:g.7674886A>C
cDNA c.645T>G
Protein p.S215R
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001126112 chr17:g.7674886A>C c.645T>G p.S215R RefSeq GRCh38/hg38
NM_001407270.1 chr17:g.7674886A>C c.645T>G p.S215R RefSeq GRCh38/hg38
NM_000546.5 chr17:g.7674886A>C c.645T>G p.S215R RefSeq GRCh38/hg38
NM_001126114 chr17:g.7674886A>C c.645T>G p.S215R RefSeq GRCh38/hg38
NM_000546 chr17:g.7674886A>C c.645T>G p.S215R RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.7674886A>C c.645T>G p.S215R RefSeq GRCh38/hg38
NM_001126114.3 chr17:g.7674886A>C c.645T>G p.S215R RefSeq GRCh38/hg38
NM_001407268.1 chr17:g.7674886A>C c.645T>G p.S215R RefSeq GRCh38/hg38
NM_001407264.1 chr17:g.7674886A>C c.645T>G p.S215R RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.7674886A>C c.645T>G p.S215R RefSeq GRCh38/hg38
NM_001126113.3 chr17:g.7674886A>C c.645T>G p.S215R RefSeq GRCh38/hg38
NM_001126113.2 chr17:g.7674886A>C c.645T>G p.S215R RefSeq GRCh38/hg38
NM_001126113 chr17:g.7674886A>C c.645T>G p.S215R RefSeq GRCh38/hg38
NM_001126112.2 chr17:g.7674886A>C c.645T>G p.S215R RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.7674886A>C c.645T>G p.S215R RefSeq GRCh38/hg38
NM_001126114.2 chr17:g.7674886A>C c.645T>G p.S215R RefSeq GRCh38/hg38
NM_000546.6 chr17:g.7674886A>C c.645T>G p.S215R RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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  • Click on any column header arrows to sort by that column
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Molecular Profile Protein Effect Treatment Approaches
TP53 S215R unknown