FGFR2 F276C
Gene Variant Detail

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Gene FGFR2
Variant F276C
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions FGFR2 F276C lies within the Ig-like C2-type domain 3 of the Fgfr2 protein (UniPort.org). F276C results in increased Fgfr2 expression, altered cellular localization, and ligand-independent Erk phosphorylation in culture (PMID: 30761385).
Associated Drug Resistance
Category Variants Paths

FGFR2 mutant FGFR2 act mut FGFR2 F276C

FGFR2 mutant FGFR2 exon7 FGFR2 F276C

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Transcript NM_000141.5
gDNA chr10:g.121520091A>C
cDNA c.827T>G
Protein p.F276C
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_022970 chr10:g.121520091A>C c.827T>G p.F276C RefSeq GRCh38/hg38
NM_001144913.1 chr10:g.121520091A>C c.827T>G p.F276C RefSeq GRCh38/hg38
NM_001144917.2 chr10:g.121520091A>C c.827T>G p.F276C RefSeq GRCh38/hg38
NM_000141.5 chr10:g.121520091A>C c.827T>G p.F276C RefSeq GRCh38/hg38
NM_001144913.1 chr10:g.121520091A>C c.827T>G p.F276C RefSeq GRCh38/hg38
NM_001144913 chr10:g.121520091A>C c.827T>G p.F276C RefSeq GRCh38/hg38
NM_001144917 chr10:g.121520091A>C c.827T>G p.F276C RefSeq GRCh38/hg38
NM_022970.3 chr10:g.121520091A>C c.827T>G p.F276C RefSeq GRCh38/hg38
NM_000141 chr10:g.121520091A>C c.827T>G p.F276C RefSeq GRCh38/hg38
NM_000141.4 chr10:g.121520091A>C c.827T>G p.F276C RefSeq GRCh38/hg38
NM_001320658.2 chr10:g.121520091A>C c.827T>G p.F276C RefSeq GRCh38/hg38
NM_022970.4 chr10:g.121520091A>C c.827T>G p.F276C RefSeq GRCh38/hg38
NM_001320658.1 chr10:g.121520091A>C c.827T>G p.F276C RefSeq GRCh38/hg38
NM_001320658 chr10:g.121520091A>C c.827T>G p.F276C RefSeq GRCh38/hg38
NM_001144917.1 chr10:g.121520091A>C c.827T>G p.F276C RefSeq GRCh38/hg38

Filtering

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Protein Effect Treatment Approaches
FGFR2 F276C gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor