RAD51C L265*
Gene Variant Detail

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Gene RAD51C
Variant L265*
Impact List nonsense
Protein Effect loss of function - predicted
Gene Variant Descriptions RAD51C L265* results in a premature truncation of the Rad51c protein at amino acid 265 of 376 (UniProt.org). L265* results in decreased binding to Rad51b in a yeast two-hybrid assay (PMID: 14704354), and therefore, is predicted to lead to a loss of Rad51c protein function.
Associated Drug Resistance
Category Variants Paths

RAD51C mutant RAD51C inact mut RAD51C L265*

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Transcript NM_058216.3
gDNA chr17:g.58709946_58709947delCTinsTA
cDNA c.793_794delCTinsTA
Protein p.L265*
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_006722002.5 chr17:g.58709946_58709947delCTinsTA c.793_794delCTinsTA p.L265* RefSeq GRCh38/hg38
NM_058216.3 chr17:g.58709946_58709947delCTinsTA c.793_794delCTinsTA p.L265* RefSeq GRCh38/hg38
XM_006722002 chr17:g.58709946_58709947delCTinsTA c.793_794delCTinsTA p.L265* RefSeq GRCh38/hg38
XM_006722002.4 chr17:g.58709946_58709947delCTinsTA c.793_794delCTinsTA p.L265* RefSeq GRCh38/hg38
XM_006722001.5 chr17:g.58709946_58709947delCTinsTA c.793_794delCTinsTA p.L265* RefSeq GRCh38/hg38
NM_058216 chr17:g.58709946_58709947delCTinsTA c.793_794delCTinsTA p.L265* RefSeq GRCh38/hg38
XM_006722001 chr17:g.58709946_58709947delCTinsTA c.793_794delCTinsTA p.L265* RefSeq GRCh38/hg38
NM_058216.2 chr17:g.58709946_58709947delCTinsTA c.793_794delCTinsTA p.L265* RefSeq GRCh38/hg38
XM_006722001.4 chr17:g.58709946_58709947delCTinsTA c.793_794delCTinsTA p.L265* RefSeq GRCh38/hg38

Filtering

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References