RAD51C E146*
Gene Variant Detail

Request Content

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@genomenon.com

Gene RAD51C
Variant E146*
Impact List nonsense
Protein Effect loss of function - predicted
Gene Variant Descriptions RAD51C E146* results in a premature truncation of the Rad51c protein at amino acid 146 of 376 (UniProt.org). E146* results in decreased binding to Rad51b in a yeast two-hybrid assay (PMID: 14704354), and due to the effects of truncation mutations downstream of E146 (PMID: 28588062), is predicted to lead to a loss of Rad51 protein function.
Associated Drug Resistance
Category Variants Paths

RAD51C mutant RAD51C inact mut RAD51C E146*

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Transcript NM_058216.3
gDNA chr17:g.58696724G>T
cDNA c.436G>T
Protein p.E146*
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_006722002 chr17:g.58696724G>T c.436G>T p.E146* RefSeq GRCh38/hg38
XM_006722002.4 chr17:g.58696724G>T c.436G>T p.E146* RefSeq GRCh38/hg38
NM_058216 chr17:g.58696724G>T c.436G>T p.E146* RefSeq GRCh38/hg38
XM_006722001.5 chr17:g.58696724G>T c.436G>T p.E146* RefSeq GRCh38/hg38
XM_006722001.4 chr17:g.58696724G>T c.436G>T p.E146* RefSeq GRCh38/hg38
NM_058216.3 chr17:g.58696724G>T c.436G>T p.E146* RefSeq GRCh38/hg38
XM_006722001 chr17:g.58696724G>T c.436G>T p.E146* RefSeq GRCh38/hg38
NM_058216.2 chr17:g.58696724G>T c.436G>T p.E146* RefSeq GRCh38/hg38
XM_006722002.5 chr17:g.58696724G>T c.436G>T p.E146* RefSeq GRCh38/hg38
XM_047436505.1 chr17:g.58696724G>T c.436G>T p.E146* RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
RAD51C E146* loss of function - predicted Olaparib