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Gene RAD51C
Variant E80*
Impact List nonsense
Protein Effect loss of function
Gene Variant Descriptions RAD51C E80* results in a premature truncation of the Rad51c protein at amino acid 80 of 376 (UniProt.org). E80* confers a loss of function to the Rad51c protein as indicated by decreased binding to Rad51b, Xrcc3, and Rad51d in yeast two-hybrid assays (PMID: 14704354).
Associated Drug Resistance
Category Variants Paths

RAD51C mutant RAD51C inact mut RAD51C E80*

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Transcript NM_058216.3
gDNA chr17:g.58695023G>T
cDNA c.238G>T
Protein p.E80*
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_006722005.3 chr17:g.58703213G>T c.238G>T p.E80* RefSeq GRCh38/hg38
XM_006722001.5 chr17:g.58695023G>T c.238G>T p.E80* RefSeq GRCh38/hg38
XM_047436505.1 chr17:g.58695023G>T c.238G>T p.E80* RefSeq GRCh38/hg38
XM_006722004 chr17:g.58703213G>T c.238G>T p.E80* RefSeq GRCh38/hg38
XM_006722002 chr17:g.58695023G>T c.238G>T p.E80* RefSeq GRCh38/hg38
XM_011525093.2 chr17:g.58703213G>T c.238G>T p.E80* RefSeq GRCh38/hg38
NM_058216.2 chr17:g.58695023G>T c.238G>T p.E80* RefSeq GRCh38/hg38
XM_017024917.1 chr17:g.58703213G>T c.238G>T p.E80* RefSeq GRCh38/hg38
XM_011525092 chr17:g.58703213G>T c.238G>T p.E80* RefSeq GRCh38/hg38
XM_017024914.1 chr17:g.58703213G>T c.238G>T p.E80* RefSeq GRCh38/hg38
XM_017024916.1 chr17:g.58703213G>T c.238G>T p.E80* RefSeq GRCh38/hg38
NM_058216.3 chr17:g.58695023G>T c.238G>T p.E80* RefSeq GRCh38/hg38
XM_017024916 chr17:g.58703213G>T c.238G>T p.E80* RefSeq GRCh38/hg38
NM_002876.4 chr17:g.58695023G>T c.238G>T p.E80* RefSeq GRCh38/hg38
XM_006722004.3 chr17:g.58703213G>T c.238G>T p.E80* RefSeq GRCh38/hg38
XM_006722002.4 chr17:g.58695023G>T c.238G>T p.E80* RefSeq GRCh38/hg38
XM_011525094 chr17:g.58703213G>T c.238G>T p.E80* RefSeq GRCh38/hg38
XM_017024919.1 chr17:g.58703213G>T c.238G>T p.E80* RefSeq GRCh38/hg38
XM_017024914 chr17:g.58703213G>T c.238G>T p.E80* RefSeq GRCh38/hg38
XM_011525093 chr17:g.58703213G>T c.238G>T p.E80* RefSeq GRCh38/hg38
XM_006722004.4 chr17:g.58703213G>T c.238G>T p.E80* RefSeq GRCh38/hg38
NM_058216 chr17:g.58695023G>T c.238G>T p.E80* RefSeq GRCh38/hg38
XM_017024919 chr17:g.58703213G>T c.238G>T p.E80* RefSeq GRCh38/hg38
XM_011525094.3 chr17:g.58703213G>T c.238G>T p.E80* RefSeq GRCh38/hg38
XM_006722002.5 chr17:g.58695023G>T c.238G>T p.E80* RefSeq GRCh38/hg38
NM_002876.3 chr17:g.58695023G>T c.238G>T p.E80* RefSeq GRCh38/hg38
XM_017024918.2 chr17:g.58703213G>T c.238G>T p.E80* RefSeq GRCh38/hg38
XM_017024915 chr17:g.58703213G>T c.238G>T p.E80* RefSeq GRCh38/hg38
XM_011525092.2 chr17:g.58703213G>T c.238G>T p.E80* RefSeq GRCh38/hg38
XM_006722001 chr17:g.58695023G>T c.238G>T p.E80* RefSeq GRCh38/hg38
XM_017024915.1 chr17:g.58703213G>T c.238G>T p.E80* RefSeq GRCh38/hg38
XM_006722001.4 chr17:g.58695023G>T c.238G>T p.E80* RefSeq GRCh38/hg38
NM_002876 chr17:g.58695023G>T c.238G>T p.E80* RefSeq GRCh38/hg38
XM_017024918 chr17:g.58703213G>T c.238G>T p.E80* RefSeq GRCh38/hg38
XM_011525094.2 chr17:g.58703213G>T c.238G>T p.E80* RefSeq GRCh38/hg38
XM_017024917 chr17:g.58703213G>T c.238G>T p.E80* RefSeq GRCh38/hg38
XM_006722005 chr17:g.58703213G>T c.238G>T p.E80* RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References