RAD51C S105*
Gene Variant Detail

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Gene RAD51C
Variant S105*
Impact List nonsense
Protein Effect loss of function - predicted
Gene Variant Descriptions RAD51C S105* results in a premature truncation of the Rad51c protein at amino acid 105 of 376 (UniProt.org). S105* has not been characterized however, due to the effects of other truncation mutations downstream of S105 (PMID: 28588062), is predicted to lead to a loss of Rad51c protein function.
Associated Drug Resistance
Category Variants Paths

RAD51C mutant RAD51C inact mut RAD51C S105*

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Transcript NM_058216.3
gDNA chr17:g.58695099C>A
cDNA c.314C>A
Protein p.S105*
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002876 chr17:g.58695099C>A c.314C>A p.S105* RefSeq GRCh38/hg38
XM_006722001.4 chr17:g.58695099C>A c.314C>A p.S105* RefSeq GRCh38/hg38
NM_058216.3 chr17:g.58695099C>A c.314C>A p.S105* RefSeq GRCh38/hg38
XM_006722001 chr17:g.58695099C>A c.314C>A p.S105* RefSeq GRCh38/hg38
XM_006722001.5 chr17:g.58695099C>A c.314C>A p.S105* RefSeq GRCh38/hg38
NM_058216.2 chr17:g.58695099C>A c.314C>A p.S105* RefSeq GRCh38/hg38
NM_002876.4 chr17:g.58695099C>A c.314C>A p.S105* RefSeq GRCh38/hg38
XM_006722002.4 chr17:g.58695099C>A c.314C>A p.S105* RefSeq GRCh38/hg38
NM_058216 chr17:g.58695099C>A c.314C>A p.S105* RefSeq GRCh38/hg38
XM_047436505.1 chr17:g.58695099C>A c.314C>A p.S105* RefSeq GRCh38/hg38
XM_006722002 chr17:g.58695099C>A c.314C>A p.S105* RefSeq GRCh38/hg38
NM_002876.3 chr17:g.58695099C>A c.314C>A p.S105* RefSeq GRCh38/hg38
XM_006722002.5 chr17:g.58695099C>A c.314C>A p.S105* RefSeq GRCh38/hg38

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References