Gene Variant Detail

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Gene FGFR2
Variant K310R
Impact List missense
Protein Effect gain of function - predicted
Gene Variant Descriptions FGFR2 K310R lies within Ig-like C2-type domain 3 of the Fgfr2 protein (UniProt.org). K310R results in proliferation similar to wild-type Fgfr2 in a competition assay but increased transformation activity in cultured cells (PMID: 34272467), and therefore, is predicted to lead to a gain of Fgfr2 protein function.
Associated Drug Resistance
Category Variants Paths

FGFR2 mutant FGFR2 act mut FGFR2 K310R

FGFR2 mutant FGFR2 exon7 FGFR2 K310R

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Transcript NM_000141.5
gDNA chr10:g.121519989T>C
cDNA c.929A>G
Protein p.K310R
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_024447891.1 chr10:g.121515190T>C c.929A>G p.K310R RefSeq GRCh38/hg38
NM_001144917.2 chr10:g.121519989T>C c.929A>G p.K310R RefSeq GRCh38/hg38
NM_001144917.1 chr10:g.121519989T>C c.929A>G p.K310R RefSeq GRCh38/hg38
NM_001320658 chr10:g.121519989T>C c.929A>G p.K310R RefSeq GRCh38/hg38
XM_006717712 chr10:g.121515190T>C c.929A>G p.K310R RefSeq GRCh38/hg38
XM_017015925.3 chr10:g.121515187T>C c.929A>G p.K310R RefSeq GRCh38/hg38
NM_022970 chr10:g.121519989T>C c.929A>G p.K310R RefSeq GRCh38/hg38
NM_001144913 chr10:g.121519989T>C c.929A>G p.K310R RefSeq GRCh38/hg38
NM_022970.4 chr10:g.121519989T>C c.929A>G p.K310R RefSeq GRCh38/hg38
XM_017015924 chr10:g.121515187T>C c.929A>G p.K310R RefSeq GRCh38/hg38
NM_022970.3 chr10:g.121519989T>C c.929A>G p.K310R RefSeq GRCh38/hg38
NM_001144917 chr10:g.121519989T>C c.929A>G p.K310R RefSeq GRCh38/hg38
NM_000141.5 chr10:g.121519989T>C c.929A>G p.K310R RefSeq GRCh38/hg38
NM_001144913.1 chr10:g.121519989T>C c.929A>G p.K310R RefSeq GRCh38/hg38
XM_024447891.2 chr10:g.121515190T>C c.929A>G p.K310R RefSeq GRCh38/hg38
XM_017015925 chr10:g.121515187T>C c.929A>G p.K310R RefSeq GRCh38/hg38
NM_001320658.1 chr10:g.121519989T>C c.929A>G p.K310R RefSeq GRCh38/hg38
XM_017015925.2 chr10:g.121515187T>C c.929A>G p.K310R RefSeq GRCh38/hg38
NM_001144913.1 chr10:g.121519989T>C c.929A>G p.K310R RefSeq GRCh38/hg38
NM_000141.4 chr10:g.121519989T>C c.929A>G p.K310R RefSeq GRCh38/hg38
NM_001320658.2 chr10:g.121519989T>C c.929A>G p.K310R RefSeq GRCh38/hg38
XM_017015924.2 chr10:g.121515187T>C c.929A>G p.K310R RefSeq GRCh38/hg38
XM_017015924.3 chr10:g.121515187T>C c.929A>G p.K310R RefSeq GRCh38/hg38
NM_000141 chr10:g.121519989T>C c.929A>G p.K310R RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries