Gene Variant Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@genomenon.com

Gene DNMT3A
Variant F732del
Impact List deletion
Protein Effect unknown
Gene Variant Descriptions DNMT3A F732del results in the deletion of an amino acid in the SAM-dependent MTase C5-type domain of the Dnmt3a protein at amino acid 732 (UniProt.org). F732del has been identified in sequencing studies (PMID: 28411256, PMID: 38359296), but has not been biochemically characterized and therefore, its effect on Dnmt3a protein function is unknown (PubMed, Oct 2024).
Associated Drug Resistance
Category Variants Paths

DNMT3A mutant DNMT3A F732del

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Transcript NM_022552.5
gDNA chr2:g.25240428_25240430delAAA
cDNA c.2194_2196delTTT
Protein p.F732delF
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_011532663.2 chr2:g.25239177_25239179delAGC c.2196_2198delTGC p.A733delA RefSeq GRCh38/hg38
XM_011532662.3 chr2:g.25239196_25239198delTCA c.2195_2197delATG p.D732delD RefSeq GRCh38/hg38
XM_011532666.2 chr2:g.25234294_25234296delATA c.2195_2197delATT p.Y732delY RefSeq GRCh38/hg38
XM_047443592.1 chr2:g.25235812_25235814delCTC c.2195_2197delGGA p.R732delR RefSeq GRCh38/hg38
NM_001320893.1 chr2:g.25234367_25234369delGCC c.2194_2196delGCG p.A732delA RefSeq GRCh38/hg38
XM_017003526.2 chr2:g.25240428_25240430delAAA c.2194_2196delTTT p.F732delF RefSeq GRCh38/hg38
NM_175629 chr2:g.25240428_25240430delAAA c.2194_2196delTTT p.F732delF RefSeq GRCh38/hg38
XM_011532666 chr2:g.25234294_25234296delATA c.2195_2197delATT p.Y732delY RefSeq GRCh38/hg38
XM_011532664.3 chr2:g.25240428_25240430delAAA c.2194_2196delTTT p.F732delF RefSeq GRCh38/hg38
XM_005264175.6 chr2:g.25240428_25240430delAAA c.2194_2196delTTT p.F732delF RefSeq GRCh38/hg38
XM_005264175 chr2:g.25240428_25240430delAAA c.2194_2196delTTT p.F732delF RefSeq GRCh38/hg38
XM_011532662 chr2:g.25239196_25239198delTCA c.2195_2197delATG p.D732delD RefSeq GRCh38/hg38
NM_022552 chr2:g.25240428_25240430delAAA c.2194_2196delTTT p.F732delF RefSeq GRCh38/hg38
XM_011532664 chr2:g.25240428_25240430delAAA c.2194_2196delTTT p.F732delF RefSeq GRCh38/hg38
NM_001320893 chr2:g.25234367_25234369delGCC c.2194_2196delGCG p.A732delA RefSeq GRCh38/hg38
XM_011532663 chr2:g.25239177_25239179delAGC c.2196_2198delTGC p.A733delA RefSeq GRCh38/hg38
XM_047443594.1 chr2:g.25234342_25234344delTGA c.2195_2197delCAT p.S732delS RefSeq GRCh38/hg38
XM_011532662.2 chr2:g.25239196_25239198delTCA c.2195_2197delATG p.D732delD RefSeq GRCh38/hg38
XM_011532664.2 chr2:g.25240428_25240430delAAA c.2194_2196delTTT p.F732delF RefSeq GRCh38/hg38
NM_175629.2 chr2:g.25240428_25240430delAAA c.2194_2196delTTT p.F732delF RefSeq GRCh38/hg38
NM_022552.4 chr2:g.25240428_25240430delAAA c.2194_2196delTTT p.F732delF RefSeq GRCh38/hg38
XM_005264175.5 chr2:g.25240428_25240430delAAA c.2194_2196delTTT p.F732delF RefSeq GRCh38/hg38
NM_175629.2 chr2:g.25240428_25240430delAAA c.2194_2196delTTT p.F732delF RefSeq GRCh38/hg38
XM_047443593.1 chr2:g.25240428_25240430delAAA c.2194_2196delTTT p.F732delF RefSeq GRCh38/hg38
NM_022552.5 chr2:g.25240428_25240430delAAA c.2194_2196delTTT p.F732delF RefSeq GRCh38/hg38
XM_017003526 chr2:g.25240428_25240430delAAA c.2194_2196delTTT p.F732delF RefSeq GRCh38/hg38
XM_017003526.1 chr2:g.25240428_25240430delAAA c.2194_2196delTTT p.F732delF RefSeq GRCh38/hg38
XM_011532666.3 chr2:g.25234294_25234296delATA c.2195_2197delATT p.Y732delY RefSeq GRCh38/hg38
NM_001320893.1 chr2:g.25234367_25234369delGCC c.2194_2196delGCG p.A732delA RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References