FGFR1 G687R
Gene Variant Detail

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Gene FGFR1
Variant G687R
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions FGFR1 G687R lies within the protein kinase domain of the Fgfr1 protein (UniProt.org). G687R results in decreased Fgfr1 expression in culture, decreased response to Fgf ligand in an in vitro assay, and decreased phosphorylation of Erk1/2 in culture (PMID: 32666525).
Associated Drug Resistance
Category Variants Paths

FGFR1 mutant FGFR1 inact mut FGFR1 G687R

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Transcript NM_023110.3
gDNA chr8:g.38414279C>T
cDNA c.2059G>A
Protein p.G687R
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001174064 chr8:g.38414249C>G c.2059G>C p.G687R RefSeq GRCh38/hg38
NM_001174064.2 chr8:g.38414249C>G c.2059G>C p.G687R RefSeq GRCh38/hg38
NM_023110.2 chr8:g.38414279C>T c.2059G>A p.G687R RefSeq GRCh38/hg38
NM_001174064.1 chr8:g.38414249C>G c.2059G>C p.G687R RefSeq GRCh38/hg38
XM_006716303.4 chr8:g.38414279C>T c.2059G>A p.G687R RefSeq GRCh38/hg38
XM_006716303.3 chr8:g.38414279C>T c.2059G>A p.G687R RefSeq GRCh38/hg38
XM_006716304 chr8:g.38414279C>T c.2059G>A p.G687R RefSeq GRCh38/hg38
XM_017013221 chr8:g.38414279C>T c.2059G>A p.G687R RefSeq GRCh38/hg38
XM_006716304.2 chr8:g.38414279C>T c.2059G>A p.G687R RefSeq GRCh38/hg38
XM_006716303 chr8:g.38414279C>T c.2059G>A p.G687R RefSeq GRCh38/hg38
XM_017013221.1 chr8:g.38414279C>T c.2059G>A p.G687R RefSeq GRCh38/hg38
NM_023110 chr8:g.38414279C>T c.2059G>A p.G687R RefSeq GRCh38/hg38
XM_017013221.2 chr8:g.38414279C>T c.2059G>A p.G687R RefSeq GRCh38/hg38
XM_006716304.1 chr8:g.38414279C>T c.2059G>A p.G687R RefSeq GRCh38/hg38
NM_023110.3 chr8:g.38414279C>T c.2059G>A p.G687R RefSeq GRCh38/hg38

Filtering

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Protein Effect Treatment Approaches
FGFR1 G687R loss of function