ATR R989C
Gene Variant Detail

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Gene ATR
Variant R989C
Impact List missense
Protein Effect unknown
Gene Variant Descriptions ATR R989C does not lie within any known functional domains of the Atr protein (UniProt.org). R989C has been identified in the sequencing studies (PMID: 27159395, PMID: 25801821, PMID: 39001563), but has not been biochemically characterized and therefore, its effect on Atr protein function is unknown (PubMed, Jul 2025).
Associated Drug Resistance
Category Variants Paths

ATR mutant ATR R989C

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Transcript NM_001184.4
gDNA chr3:g.142550143G>A
cDNA c.2965C>T
Protein p.R989C
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001184 chr3:g.142550143G>A c.2965C>T p.R989C RefSeq GRCh38/hg38
XM_011512924.2 chr3:g.142550143G>A c.2965C>T p.R989C RefSeq GRCh38/hg38
XM_047448361.1 chr3:g.142550143G>A c.2965C>T p.R989C RefSeq GRCh38/hg38
XM_011512924.1 chr3:g.142550143G>A c.2965C>T p.R989C RefSeq GRCh38/hg38
XM_047448363.1 chr3:g.142550143G>A c.2965C>T p.R989C RefSeq GRCh38/hg38
XM_011512926 chr3:g.142550143G>A c.2965C>T p.R989C RefSeq GRCh38/hg38
NM_001184.3 chr3:g.142550143G>A c.2965C>T p.R989C RefSeq GRCh38/hg38
XM_047448362.1 chr3:g.142550143G>A c.2965C>T p.R989C RefSeq GRCh38/hg38
XM_047448364.1 chr3:g.142550143G>A c.2965C>T p.R989C RefSeq GRCh38/hg38
XM_011512924 chr3:g.142550143G>A c.2965C>T p.R989C RefSeq GRCh38/hg38
XM_047448360.1 chr3:g.142550143G>A c.2965C>T p.R989C RefSeq GRCh38/hg38
NM_001184.4 chr3:g.142550143G>A c.2965C>T p.R989C RefSeq GRCh38/hg38

Filtering

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References