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Gene RAD51B
Variant Y46*
Impact List nonsense
Protein Effect loss of function - predicted
Gene Variant Descriptions RAD51B Y46* results in a premature truncation of the Rad51b protein at aa 46 of 384 (UniProt.org). Y46* has not been characterized, however, due to the effects of truncation mutations downstream of Y46 (PMID: 9788630), is predicted to lead to a loss of Rad51b protein function.
Associated Drug Resistance
Category Variants Paths

RAD51B mutant RAD51B inact mut RAD51B Y46*

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Transcript NM_133509.5
gDNA chr14:g.67825517T>A
cDNA c.138T>A
Protein p.Y46*
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002877.5 chr14:g.67825517T>A c.138T>A p.Y46* RefSeq GRCh38/hg38
NM_133509.5 chr14:g.67825517T>A c.138T>A p.Y46* RefSeq GRCh38/hg38
NM_133510 chr14:g.67825517T>A c.138T>A p.Y46* RefSeq GRCh38/hg38
NM_001321818.2 chr14:g.67825517T>A c.138T>A p.Y46* RefSeq GRCh38/hg38
NM_001321819 chr14:g.67825517T>A c.138T>A p.Y46* RefSeq GRCh38/hg38
XM_011537050 chr14:g.67825517T>A c.138T>A p.Y46* RefSeq GRCh38/hg38
NM_001321819.1 chr14:g.67825517T>A c.138T>A p.Y46* RefSeq GRCh38/hg38
NM_001321812 chr14:g.67825517T>A c.138T>A p.Y46* RefSeq GRCh38/hg38
NM_133509 chr14:g.67825517T>A c.138T>A p.Y46* RefSeq GRCh38/hg38
NM_001321809 chr14:g.67825517T>A c.138T>A p.Y46* RefSeq GRCh38/hg38
XM_011537051 chr14:g.67825517T>A c.138T>A p.Y46* RefSeq GRCh38/hg38
NM_001321821 chr14:g.67825517T>A c.138T>A p.Y46* RefSeq GRCh38/hg38
NM_001321814 chr14:g.67825517T>A c.138T>A p.Y46* RefSeq GRCh38/hg38
NM_001321819.1 chr14:g.67825517T>A c.138T>A p.Y46* RefSeq GRCh38/hg38
XM_017021545.2 chr14:g.67825517T>A c.138T>A p.Y46* RefSeq GRCh38/hg38
XM_011537050.3 chr14:g.67825517T>A c.138T>A p.Y46* RefSeq GRCh38/hg38
NM_001321810.2 chr14:g.67825517T>A c.138T>A p.Y46* RefSeq GRCh38/hg38
NM_001321809.1 chr14:g.67825517T>A c.138T>A p.Y46* RefSeq GRCh38/hg38
NM_001321814.2 chr14:g.67825517T>A c.138T>A p.Y46* RefSeq GRCh38/hg38
NM_133509.3 chr14:g.67825517T>A c.138T>A p.Y46* RefSeq GRCh38/hg38
NM_002877 chr14:g.67825517T>A c.138T>A p.Y46* RefSeq GRCh38/hg38
NM_001321818.1 chr14:g.67825517T>A c.138T>A p.Y46* RefSeq GRCh38/hg38
NM_001321810.1 chr14:g.67825517T>A c.138T>A p.Y46* RefSeq GRCh38/hg38
NM_001321821.2 chr14:g.67825517T>A c.138T>A p.Y46* RefSeq GRCh38/hg38
NM_001321812.1 chr14:g.67825517T>A c.138T>A p.Y46* RefSeq GRCh38/hg38
NM_001321810 chr14:g.67825517T>A c.138T>A p.Y46* RefSeq GRCh38/hg38
NM_001321821.1 chr14:g.67825517T>A c.138T>A p.Y46* RefSeq GRCh38/hg38
NM_001321814.1 chr14:g.67825517T>A c.138T>A p.Y46* RefSeq GRCh38/hg38
XM_017021545 chr14:g.67825517T>A c.138T>A p.Y46* RefSeq GRCh38/hg38
NM_001321809.2 chr14:g.67825517T>A c.138T>A p.Y46* RefSeq GRCh38/hg38
NM_001321812.1 chr14:g.67825517T>A c.138T>A p.Y46* RefSeq GRCh38/hg38
NM_133510.3 chr14:g.67825517T>A c.138T>A p.Y46* RefSeq GRCh38/hg38
NM_002877.6 chr14:g.67825517T>A c.138T>A p.Y46* RefSeq GRCh38/hg38
NM_001321818 chr14:g.67825517T>A c.138T>A p.Y46* RefSeq GRCh38/hg38
NM_133510.4 chr14:g.67825517T>A c.138T>A p.Y46* RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
RAD51B Y46* loss of function - predicted Olaparib