RAD51B L103*
Gene Variant Detail

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Gene RAD51B
Variant L103*
Impact List nonsense
Protein Effect loss of function - predicted
Gene Variant Descriptions RAD51B L103* results in a premature truncation of the Rad51b protein at amino acid 103 of 384 (UniProt.org). L103* is predicted to lead to a loss of Rad51b protein function as the corresponding variant in an alternative isoform (L103*) fails to delay G1 cell cycle transition and does not induce apoptosis upon irradiation in cultured cells (PMID: 9788630).
Associated Drug Resistance
Category Variants Paths

RAD51B mutant RAD51B inact mut RAD51B L103*

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Transcript NM_133509.5
gDNA chr14:g.67835188_67835190delCTCinsTAA
cDNA c.307_309delCTCinsTAA
Protein p.L103*
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001321818 chr14:g.67835188_67835190delCTCinsTAA c.307_309delCTCinsTAA p.L103* RefSeq GRCh38/hg38
NM_133509.5 chr14:g.67835188_67835190delCTCinsTAA c.307_309delCTCinsTAA p.L103* RefSeq GRCh38/hg38
NM_001321812 chr14:g.67835188_67835190delCTCinsTAA c.307_309delCTCinsTAA p.L103* RefSeq GRCh38/hg38
NM_001321821 chr14:g.67835188_67835190delCTCinsTAA c.307_309delCTCinsTAA p.L103* RefSeq GRCh38/hg38
NM_001321821.2 chr14:g.67835188_67835190delCTCinsTAA c.307_309delCTCinsTAA p.L103* RefSeq GRCh38/hg38
XM_017021545 chr14:g.67835188_67835190delCTCinsTAA c.307_309delCTCinsTAA p.L103* RefSeq GRCh38/hg38
NM_133509.3 chr14:g.67835188_67835190delCTCinsTAA c.307_309delCTCinsTAA p.L103* RefSeq GRCh38/hg38
NM_002877.5 chr14:g.67835188_67835190delCTCinsTAA c.307_309delCTCinsTAA p.L103* RefSeq GRCh38/hg38
NM_001321810 chr14:g.67835188_67835190delCTCinsTAA c.307_309delCTCinsTAA p.L103* RefSeq GRCh38/hg38
NM_001321809.1 chr14:g.67835188_67835190delCTCinsTAA c.307_309delCTCinsTAA p.L103* RefSeq GRCh38/hg38
NM_001321812.1 chr14:g.67835188_67835190delCTCinsTAA c.307_309delCTCinsTAA p.L103* RefSeq GRCh38/hg38
NM_002877.6 chr14:g.67835188_67835190delCTCinsTAA c.307_309delCTCinsTAA p.L103* RefSeq GRCh38/hg38
NM_133510.3 chr14:g.67835188_67835190delCTCinsTAA c.307_309delCTCinsTAA p.L103* RefSeq GRCh38/hg38
NM_133509 chr14:g.67835188_67835190delCTCinsTAA c.307_309delCTCinsTAA p.L103* RefSeq GRCh38/hg38
NM_001321814.1 chr14:g.67835188_67835190delCTCinsTAA c.307_309delCTCinsTAA p.L103* RefSeq GRCh38/hg38
NM_133510.4 chr14:g.67835188_67835190delCTCinsTAA c.307_309delCTCinsTAA p.L103* RefSeq GRCh38/hg38
NM_001321814.2 chr14:g.67835188_67835190delCTCinsTAA c.307_309delCTCinsTAA p.L103* RefSeq GRCh38/hg38
NM_001321821.1 chr14:g.67835188_67835190delCTCinsTAA c.307_309delCTCinsTAA p.L103* RefSeq GRCh38/hg38
XM_011537050.3 chr14:g.67835188_67835190delCTCinsTAA c.307_309delCTCinsTAA p.L103* RefSeq GRCh38/hg38
NM_001321814 chr14:g.67835188_67835190delCTCinsTAA c.307_309delCTCinsTAA p.L103* RefSeq GRCh38/hg38
NM_001321812.1 chr14:g.67835188_67835190delCTCinsTAA c.307_309delCTCinsTAA p.L103* RefSeq GRCh38/hg38
NM_001321809.2 chr14:g.67835188_67835190delCTCinsTAA c.307_309delCTCinsTAA p.L103* RefSeq GRCh38/hg38
NM_133510 chr14:g.67835188_67835190delCTCinsTAA c.307_309delCTCinsTAA p.L103* RefSeq GRCh38/hg38
NM_001321819 chr14:g.67835188_67835190delCTCinsTAA c.307_309delCTCinsTAA p.L103* RefSeq GRCh38/hg38
XM_011537051 chr14:g.67835188_67835190delCTCinsTAA c.307_309delCTCinsTAA p.L103* RefSeq GRCh38/hg38
NM_001321819.1 chr14:g.67835188_67835190delCTCinsTAA c.307_309delCTCinsTAA p.L103* RefSeq GRCh38/hg38
NM_001321818.1 chr14:g.67835188_67835190delCTCinsTAA c.307_309delCTCinsTAA p.L103* RefSeq GRCh38/hg38
NM_002877 chr14:g.67835188_67835190delCTCinsTAA c.307_309delCTCinsTAA p.L103* RefSeq GRCh38/hg38
XM_011537050 chr14:g.67835188_67835190delCTCinsTAA c.307_309delCTCinsTAA p.L103* RefSeq GRCh38/hg38
NM_001321818.2 chr14:g.67835188_67835190delCTCinsTAA c.307_309delCTCinsTAA p.L103* RefSeq GRCh38/hg38
NM_001321819.1 chr14:g.67835188_67835190delCTCinsTAA c.307_309delCTCinsTAA p.L103* RefSeq GRCh38/hg38
XM_017021545.2 chr14:g.67835188_67835190delCTCinsTAA c.307_309delCTCinsTAA p.L103* RefSeq GRCh38/hg38
NM_001321809 chr14:g.67835188_67835190delCTCinsTAA c.307_309delCTCinsTAA p.L103* RefSeq GRCh38/hg38
NM_001321810.1 chr14:g.67835188_67835190delCTCinsTAA c.307_309delCTCinsTAA p.L103* RefSeq GRCh38/hg38
NM_001321810.2 chr14:g.67835188_67835190delCTCinsTAA c.307_309delCTCinsTAA p.L103* RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References