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Gene FGFR2
Variant Q259*
Impact List nonsense
Protein Effect loss of function - predicted
Gene Variant Descriptions FGFR2 Q259* results in a premature truncation of the Fgfr2 protein at amino acid 259 of 821 (UniProt.org). Q259* results in similar cell proliferation and viability levels as wild-type Fgfr2 in two different cell lines (PMID: 29533785), but decreased proliferation relative to wild-type Fgfr2 in a competition assay and decreased transformation activity in cultured cells (PMID: 34272467), and therefore, is predicted to lead to a loss of Fgfr2 protein function.
Associated Drug Resistance
Category Variants Paths

FGFR2 mutant FGFR2 exon7 FGFR2 Q259*

FGFR2 mutant FGFR2 inact mut FGFR2 Q259*

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Transcript NM_000141.5
gDNA chr10:g.121520143G>A
cDNA c.775C>T
Protein p.Q259*
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001144913 chr10:g.121520143G>A c.775C>T p.Q259* RefSeq GRCh38/hg38
NM_001144913.1 chr10:g.121520143G>A c.775C>T p.Q259* RefSeq GRCh38/hg38
NM_001144917 chr10:g.121520143G>A c.775C>T p.Q259* RefSeq GRCh38/hg38
NM_000141.4 chr10:g.121520143G>A c.775C>T p.Q259* RefSeq GRCh38/hg38
NM_022970.4 chr10:g.121520143G>A c.775C>T p.Q259* RefSeq GRCh38/hg38
NM_001320658 chr10:g.121520143G>A c.775C>T p.Q259* RefSeq GRCh38/hg38
NM_001144917.1 chr10:g.121520143G>A c.775C>T p.Q259* RefSeq GRCh38/hg38
NM_001144917.2 chr10:g.121520143G>A c.775C>T p.Q259* RefSeq GRCh38/hg38
NM_022970 chr10:g.121520143G>A c.775C>T p.Q259* RefSeq GRCh38/hg38
NM_001144919.2 chr10:g.121518727G>A c.775C>T p.Q259* RefSeq GRCh38/hg38
NM_001144913.1 chr10:g.121520143G>A c.775C>T p.Q259* RefSeq GRCh38/hg38
NM_001320658.2 chr10:g.121520143G>A c.775C>T p.Q259* RefSeq GRCh38/hg38
NM_000141 chr10:g.121520143G>A c.775C>T p.Q259* RefSeq GRCh38/hg38
NM_001144919.1 chr10:g.121518727G>A c.775C>T p.Q259* RefSeq GRCh38/hg38
NM_001320658.1 chr10:g.121520143G>A c.775C>T p.Q259* RefSeq GRCh38/hg38
NM_022970.3 chr10:g.121520143G>A c.775C>T p.Q259* RefSeq GRCh38/hg38
NM_001144919 chr10:g.121518727G>A c.775C>T p.Q259* RefSeq GRCh38/hg38
NM_000141.5 chr10:g.121520143G>A c.775C>T p.Q259* RefSeq GRCh38/hg38

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References