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Gene FGFR2
Variant R251Q
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions FGFR2 R251Q lies within the region linking Ig-like domains II and III of the Fgfr2 protein (PMID: 11121055). R251Q results in proliferation similar to wild-type Fgfr2 in a competition assay and transformation activity similar to wild-type in cultured cells (PMID: 34272467), but confers a loss of function on the Fgfr2 protein as demonstrated by loss of ligand binding and diminished Mapk activation upon Fgf2 stimulation in cell culture (PMID: 19147536).
Associated Drug Resistance
Category Variants Paths

FGFR2 mutant FGFR2 exon7 FGFR2 R251Q

FGFR2 mutant FGFR2 inact mut FGFR2 R251Q

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Transcript NM_000141.5
gDNA chr10:g.121520166C>T
cDNA c.752G>A
Protein p.R251Q
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_022970.4 chr10:g.121520166C>T c.752G>A p.R251Q RefSeq GRCh38/hg38
NM_001144913 chr10:g.121520166C>T c.752G>A p.R251Q RefSeq GRCh38/hg38
NM_001144913.1 chr10:g.121520166C>T c.752G>A p.R251Q RefSeq GRCh38/hg38
NM_001144917.1 chr10:g.121520166C>T c.752G>A p.R251Q RefSeq GRCh38/hg38
NM_001144917 chr10:g.121520166C>T c.752G>A p.R251Q RefSeq GRCh38/hg38
NM_001320658 chr10:g.121520166C>T c.752G>A p.R251Q RefSeq GRCh38/hg38
NM_000141.5 chr10:g.121520166C>T c.752G>A p.R251Q RefSeq GRCh38/hg38
NM_001320658.2 chr10:g.121520166C>T c.752G>A p.R251Q RefSeq GRCh38/hg38
NM_022970 chr10:g.121520166C>T c.752G>A p.R251Q RefSeq GRCh38/hg38
NM_022970.3 chr10:g.121520166C>T c.752G>A p.R251Q RefSeq GRCh38/hg38
NM_000141 chr10:g.121520166C>T c.752G>A p.R251Q RefSeq GRCh38/hg38
NM_001144917.2 chr10:g.121520166C>T c.752G>A p.R251Q RefSeq GRCh38/hg38
NM_001320658.1 chr10:g.121520166C>T c.752G>A p.R251Q RefSeq GRCh38/hg38
NM_000141.4 chr10:g.121520166C>T c.752G>A p.R251Q RefSeq GRCh38/hg38
NM_001144913.1 chr10:g.121520166C>T c.752G>A p.R251Q RefSeq GRCh38/hg38

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FGFR2 R251Q Advanced Solid Tumor predicted - sensitive Fexagratinib Preclinical - Cell culture Actionable In a preclinical study, cells expressing FGFR2 R251Q were sensitive to treatment with AZD4547 in culture, demonstrating reduced cell viability (PMID: 34272467). 34272467
FGFR2 R251Q Advanced Solid Tumor predicted - sensitive Infigratinib Preclinical - Cell culture Actionable In a preclinical study, cells expressing FGFR2 R251Q were sensitive to treatment with Truseltiq (infigratinib) in culture, demonstrating reduced cell viability (PMID: 34272467). 34272467
FGFR2 R251Q Advanced Solid Tumor predicted - sensitive Erdafitinib Preclinical - Cell culture Actionable In a preclinical study, cells expressing FGFR2 R251Q were sensitive to treatment with Balversa (erdafitinib) in culture, demonstrating reduced cell viability (PMID: 34272467). 34272467
FGFR2 R251Q Advanced Solid Tumor predicted - sensitive Futibatinib Preclinical - Cell culture Actionable In a preclinical study, cells expressing FGFR2 R251Q were sensitive to treatment with Lytgobi (futibatinib) in culture, demonstrating reduced cell viability (PMID: 34272467). 34272467
FGFR2 R251Q Advanced Solid Tumor predicted - sensitive Pemigatinib Preclinical - Cell culture Actionable In a preclinical study, cells expressing FGFR2 R251Q were sensitive to treatment with Pemazyre (pemigatinib) in culture, demonstrating reduced cell viability (PMID: 34272467). 34272467
FGFR2 R251Q Advanced Solid Tumor predicted - sensitive E7090 Preclinical - Cell culture Actionable In a preclinical study, cells expressing FGFR2 R251Q were sensitive to treatment with E7090 in culture, demonstrating reduced cell viability (PMID: 34272467). 34272467