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Gene FGFR2
Variant R330W
Impact List missense
Protein Effect no effect - predicted
Gene Variant Descriptions FGFR2 R330W lies within Ig-like C2-type domain 3 of the Fgfr2 protein (UniProt.org). R330W results in proliferation similar to wild-type Fgfr2 in a competition assay and transformation activity similar to wild-type in cultured cells (PMID: 34272467), and therefore, is predicted to have no effect on Fgfr2 protein function.
Associated Drug Resistance
Category Variants Paths

FGFR2 mutant FGFR2 R330W

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Transcript NM_000141.5
gDNA chr10:g.121517415G>A
cDNA c.988C>T
Protein p.R330W
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_017015925.3 chr10:g.121515126_121515128delAGAinsTGG c.988_990delAGAinsTGG p.R330W RefSeq GRCh38/hg38
XM_017015924 chr10:g.121515126_121515128delTCTinsCCA c.988_990delAGAinsTGG p.R330W RefSeq GRCh38/hg38
XM_006717711 chr10:g.121515207_121515209delTCGinsCCA c.988_990delCGAinsTGG p.R330W RefSeq GRCh38/hg38
XM_024447890.2 chr10:g.121515207_121515209delCGAinsTGG c.988_990delCGAinsTGG p.R330W RefSeq GRCh38/hg38
XM_017015924.2 chr10:g.121515126_121515128delAGAinsTGG c.988_990delAGAinsTGG p.R330W RefSeq GRCh38/hg38
NM_001320658.2 chr10:g.121517415G>A c.988C>T p.R330W RefSeq GRCh38/hg38
XM_017015925.2 chr10:g.121515126_121515128delAGAinsTGG c.988_990delAGAinsTGG p.R330W RefSeq GRCh38/hg38
XM_024447891.2 chr10:g.121515131G>A c.988C>T p.R330W RefSeq GRCh38/hg38
XM_017015922 chr10:g.121515207_121515209delTCGinsCCA c.988_990delCGAinsTGG p.R330W RefSeq GRCh38/hg38
NM_000141 chr10:g.121517415G>A c.988C>T p.R330W RefSeq GRCh38/hg38
XM_024447890.1 chr10:g.121515207_121515209delCGAinsTGG c.988_990delCGAinsTGG p.R330W RefSeq GRCh38/hg38
NM_001144917 chr10:g.121503893T>A c.988A>T p.R330W RefSeq GRCh38/hg38
XM_017015925 chr10:g.121515126_121515128delTCTinsCCA c.988_990delAGAinsTGG p.R330W RefSeq GRCh38/hg38
NM_001144917.2 chr10:g.121503893T>A c.988A>T p.R330W RefSeq GRCh38/hg38
NM_001320658 chr10:g.121517415G>A c.988C>T p.R330W RefSeq GRCh38/hg38
XM_024447891.1 chr10:g.121515131G>A c.988C>T p.R330W RefSeq GRCh38/hg38
XM_017015924.3 chr10:g.121515126_121515128delAGAinsTGG c.988_990delAGAinsTGG p.R330W RefSeq GRCh38/hg38
NM_000141.4 chr10:g.121517415G>A c.988C>T p.R330W RefSeq GRCh38/hg38
NM_000141.5 chr10:g.121517415G>A c.988C>T p.R330W RefSeq GRCh38/hg38
XM_006717712 chr10:g.121515131G>A c.988C>T p.R330W RefSeq GRCh38/hg38
XM_024447888.1 chr10:g.121515207_121515209delCGAinsTGG c.988_990delCGAinsTGG p.R330W RefSeq GRCh38/hg38
XM_024447888.2 chr10:g.121515207_121515209delCGAinsTGG c.988_990delCGAinsTGG p.R330W RefSeq GRCh38/hg38
NM_001144917.1 chr10:g.121503893T>A c.988A>T p.R330W RefSeq GRCh38/hg38
NM_001320658.1 chr10:g.121517415G>A c.988C>T p.R330W RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FGFR2 R330W Advanced Solid Tumor predicted - sensitive Fexagratinib Preclinical - Cell culture Actionable In a preclinical study, cells expressing FGFR2 R330W were sensitive to treatment with AZD4547 in culture, demonstrating reduced cell viability (PMID: 34272467). 34272467
FGFR2 R330W Advanced Solid Tumor predicted - sensitive Infigratinib Preclinical - Cell culture Actionable In a preclinical study, cells expressing FGFR2 R330W were sensitive to treatment with Truseltiq (infigratinib) in culture, demonstrating reduced cell viability (PMID: 34272467). 34272467
FGFR2 R330W Advanced Solid Tumor predicted - resistant Dovitinib Preclinical - Cell culture Actionable In a preclinical study, cells expressing FGFR2 R330W were resistant to treatment with Dovitinib (TKI258) in culture (PMID: 34272467). 34272467
FGFR2 R330W Advanced Solid Tumor predicted - sensitive Erdafitinib Preclinical - Cell culture Actionable In a preclinical study, cells expressing FGFR2 R330W were sensitive to treatment with Balversa (erdafitinib) in culture, demonstrating reduced cell viability (PMID: 34272467). 34272467
FGFR2 R330W Advanced Solid Tumor predicted - sensitive Futibatinib Preclinical - Cell culture Actionable In a preclinical study, cells expressing FGFR2 R330W were sensitive to treatment with Lytgobi (futibatinib) in culture, demonstrating reduced cell viability (PMID: 34272467). 34272467
FGFR2 R330W Advanced Solid Tumor predicted - sensitive Pemigatinib Preclinical - Cell culture Actionable In a preclinical study, cells expressing FGFR2 R330W were sensitive to treatment with Pemazyre (pemigatinib) in culture, demonstrating reduced cell viability (PMID: 34272467). 34272467
FGFR2 R330W Advanced Solid Tumor predicted - sensitive E7090 Preclinical - Cell culture Actionable In a preclinical study, cells expressing FGFR2 R330W were sensitive to treatment with E7090 in culture, demonstrating reduced cell viability (PMID: 34272467). 34272467