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Gene TP53
Variant W91Gfs*32
Impact List frameshift
Protein Effect loss of function - predicted
Gene Variant Descriptions TP53 W91Gfs*32 indicates a shift in the reading frame starting at amino acid 91 and terminating 32 residues downstream causing a premature truncation of the 393 amino acid Tp53 protein (UniProt.org). W91Gfs*32 maintains induction of apoptosis, but results in altered subcellular localization and a loss of transcriptional transactivation activity in a reporter assay (PMID: 31081129), and therefore, is predicted to lead to a loss of Tp53 protein function.
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon4 TP53 W91fs TP53 W91Gfs*32

TP53 mutant TP53 inact mut TP53 W91fs TP53 W91Gfs*32

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Transcript NM_000546.6
gDNA chr17:g.7676098delA
cDNA c.271delT
Protein p.W91Gfs*32
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001126112.3 chr17:g.7676098delA c.271delT p.W91Gfs*32 RefSeq GRCh38/hg38
NM_000546.6 chr17:g.7676098delA c.271delT p.W91Gfs*32 RefSeq GRCh38/hg38
NM_001126114 chr17:g.7676098delA c.271delT p.W91Gfs*32 RefSeq GRCh38/hg38
NM_001407264.1 chr17:g.7676098delA c.271delT p.W91Gfs*32 RefSeq GRCh38/hg38
NM_001407270.1 chr17:g.7676098delA c.271delT p.W91Gfs*32 RefSeq GRCh38/hg38
NM_001126113.3 chr17:g.7676098delA c.271delT p.W91Gfs*32 RefSeq GRCh38/hg38
NM_001126113.2 chr17:g.7676098delA c.271delT p.W91Gfs*32 RefSeq GRCh38/hg38
NM_000546.5 chr17:g.7676098delA c.271delT p.W91Gfs*32 RefSeq GRCh38/hg38
NM_001126114.2 chr17:g.7676098delA c.271delT p.W91Gfs*32 RefSeq GRCh38/hg38
NM_001407268.1 chr17:g.7676098delA c.271delT p.W91Gfs*32 RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.7676098delA c.271delT p.W91Gfs*32 RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.7676098delA c.271delT p.W91Gfs*32 RefSeq GRCh38/hg38
NM_001126112 chr17:g.7676098delA c.271delT p.W91Gfs*32 RefSeq GRCh38/hg38
NM_001126113 chr17:g.7676098delA c.271delT p.W91Gfs*32 RefSeq GRCh38/hg38
NM_001126112.2 chr17:g.7676098delA c.271delT p.W91Gfs*32 RefSeq GRCh38/hg38
NM_001126114.3 chr17:g.7676098delA c.271delT p.W91Gfs*32 RefSeq GRCh38/hg38
NM_000546 chr17:g.7676098delA c.271delT p.W91Gfs*32 RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References