FGFR2 S372C
Gene Variant Detail

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Gene FGFR2
Variant S372C
Impact List missense
Protein Effect gain of function - predicted
Gene Variant Descriptions FGFR2 S372C lies within the extracellular domain of the Fgfr2 protein (PMID: 17525745). S372C (also reported as S373C) results in constitutive dimerization of the receptor (PMID: 17525745), and therefore, is predicted to lead to a gain of Fgfr2 protein function.
Associated Drug Resistance
Category Variants Paths

FGFR2 mutant FGFR2 act mut FGFR2 S372C

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Transcript NM_000141.5
gDNA chr10:g.121515289G>C
cDNA c.1115C>G
Protein p.S372C
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001320658.1 chr10:g.121515289G>C c.1115C>G p.S372C RefSeq GRCh38/hg38
NM_000141.4 chr10:g.121515289G>C c.1115C>G p.S372C RefSeq GRCh38/hg38
NM_000141.5 chr10:g.121515289G>C c.1115C>G p.S372C RefSeq GRCh38/hg38
NM_000141 chr10:g.121515289G>C c.1115C>G p.S372C RefSeq GRCh38/hg38
NM_001320658.2 chr10:g.121515289G>C c.1115C>G p.S372C RefSeq GRCh38/hg38
NM_001320658 chr10:g.121515289G>C c.1115C>G p.S372C RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FGFR2 S372C cholangiocarcinoma predicted - sensitive Lenvatinib Case Reports/Case Series Actionable In a clinical case study, Lenvima (lenvatinib) treatment resulted in a partial response in a patient with cholangiocarcinoma harboring FGFR2 S372C (PMID: 38346946). 38346946