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RAD51D V203E - Gene Variant Detail

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Gene RAD51D
Variant V203E
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions RAD51D V203E lies within the Walker B motif region of the Rad51d protein (PMID: 30836272). V203E fails to restore mitomycin sensitivity in cell culture and demonstrates reduced ability to bind Xrcc2 and Rad51c in yeast assays (PMID: 16717288).
Associated Drug Resistance
Category Variants Paths

RAD51D mutant RAD51D inact mut RAD51D V203E

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Transcript NM_002878.4
gDNA chr17:g.35103513A>T
cDNA c.608T>A
Protein p.V203E
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002878 chr17:g.35103513A>T c.608T>A p.V203E RefSeq GRCh38/hg38
NM_002878.4 chr17:g.35103513A>T c.608T>A p.V203E RefSeq GRCh38/hg38
NM_002878.3 chr17:g.35103513A>T c.608T>A p.V203E RefSeq GRCh38/hg38

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References