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Gene RAD51D
Variant K113R
Impact List missense
Protein Effect unknown
Gene Variant Descriptions RAD51D K113R lies within the Walker A motif region of the Rad51d protein (PMID: 30836272). The functional effect of K113R is conflicting, as it restores mitomycin sensitivity and retains the ability to interact with Xrcc2 similar to wild-type Rad51d (PMID: 16717288, PMID: 16236763), however, fails to restore mitomycin-induced DNA damage, and demonstrates reduced homologous recombination repair ability, and decreased binding to Rad51c in cell culture (PMID: 16236763, PMID: 16717288, PMID: 30836272), and therefore, its effect on Rad51d protein function is unknown.
Associated Drug Resistance
Category Variants Paths

RAD51D mutant RAD51D K113R

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Transcript NM_002878.4
gDNA chr17:g.35107373T>C
cDNA c.338A>G
Protein p.K113R
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002878.3 chr17:g.35107373T>C c.338A>G p.K113R RefSeq GRCh38/hg38
NM_002878 chr17:g.35107373T>C c.338A>G p.K113R RefSeq GRCh38/hg38
NM_002878.4 chr17:g.35107373T>C c.338A>G p.K113R RefSeq GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References