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Gene PTEN
Variant R142W
Impact List missense
Protein Effect loss of function - predicted
Gene Variant Descriptions PTEN R142W lies within the phosphatase tensin-type domain of the Pten protein (UniProt.org). R142W demonstrates protein stability similar to wild-type Pten and suppresses Akt signaling similar to wild-type Pten (PMID: 32704382), but results in reduced ability to rescue spheroid formation in culture (PMID: 32366478), and therefore, is predicted to lead to a loss of Pten protein function.
Associated Drug Resistance
Category Variants Paths

PTEN mutant PTEN inact mut PTEN R142W

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Transcript NM_000314.8
gDNA chr10:g.87933183C>T
cDNA c.424C>T
Protein p.R142W
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000314 chr10:g.87933183C>T c.424C>T p.R142W RefSeq GRCh38/hg38
NM_000314.6 chr10:g.87933183C>T c.424C>T p.R142W RefSeq GRCh38/hg38
NM_000314.8 chr10:g.87933183C>T c.424C>T p.R142W RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References