Missing content? – Request curation!
Request curation for specific Genes, Variants, or PubMed publications.
Have questions, comments, or suggestions? - Let us know!
Email us at : ckbsupport@genomenon.com
Gene | PTEN |
Variant | M198I |
Impact List | missense |
Protein Effect | no effect |
Gene Variant Descriptions | PTEN M198I lies within the C2 tensin-type domain of the Pten protein (UniProt.org). M198I results in Akt phosphorylation (PMID: 32350270), and demonstrates Pten protein stability and the ability to rescue spheroid formation similar to wild-type Pten in cell culture (PMID: 32366478, PMID: 32350270). |
Associated Drug Resistance | |
Category Variants Paths |
PTEN mutant PTEN M198I |
Transcript | NM_000314.8 |
gDNA | chr10:g.87952219G>C |
cDNA | c.594G>C |
Protein | p.M198I |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |
Transcript | gDNA | cDNA | Protein | Source Database | Genome Build |
---|---|---|---|---|---|
NM_000314.6 | chr10:g.87952219G>C | c.594G>C | p.M198I | RefSeq | GRCh38/hg38 |
NM_000314.8 | chr10:g.87952219G>C | c.594G>C | p.M198I | RefSeq | GRCh38/hg38 |
NM_000314 | chr10:g.87952219G>C | c.594G>C | p.M198I | RefSeq | GRCh38/hg38 |
Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
---|