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Gene FGFR3
Variant P573S
Impact List missense
Protein Effect unknown
Gene Variant Descriptions FGFR3 P573S lies within the protein kinase domain of the Fgfr3 protein (UniProt.org). P573S has not been characterized in the scientific literature and therefore, its effect on Fgfr3 protein function is unknown (PubMed, Mar 2024).
Associated Drug Resistance
Category Variants Paths

FGFR3 mutant FGFR3 P573S

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Transcript NM_000142.5
gDNA chr4:g.1805821C>T
cDNA c.1717C>T
Protein p.P573S
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_047449822.1 chr4:g.1805818C>T c.1717C>T p.P573S RefSeq GRCh38/hg38
NM_000142 chr4:g.1805821C>T c.1717C>T p.P573S RefSeq GRCh38/hg38
NM_001354810.1 chr4:g.1805818C>T c.1717C>T p.P573S RefSeq GRCh38/hg38
XM_011513422 chr4:g.1805818C>T c.1717C>T p.P573S RefSeq GRCh38/hg38
XM_006713873 chr4:g.1805821C>T c.1717C>T p.P573S RefSeq GRCh38/hg38
XM_011513422.1 chr4:g.1805818C>T c.1717C>T p.P573S RefSeq GRCh38/hg38
XM_006713873.1 chr4:g.1805821C>T c.1717C>T p.P573S RefSeq GRCh38/hg38
XM_006713873.2 chr4:g.1805821C>T c.1717C>T p.P573S RefSeq GRCh38/hg38
XM_006713872 chr4:g.1805818C>T c.1717C>T p.P573S RefSeq GRCh38/hg38
NM_001354809.2 chr4:g.1805818C>T c.1717C>T p.P573S RefSeq GRCh38/hg38
NM_000142.4 chr4:g.1805821C>T c.1717C>T p.P573S RefSeq GRCh38/hg38
NM_001354809.1 chr4:g.1805818C>T c.1717C>T p.P573S RefSeq GRCh38/hg38
NM_000142.5 chr4:g.1805821C>T c.1717C>T p.P573S RefSeq GRCh38/hg38
XM_047449823.1 chr4:g.1805821C>T c.1717C>T p.P573S RefSeq GRCh38/hg38
XM_047449824.1 chr4:g.1805821C>T c.1717C>T p.P573S RefSeq GRCh38/hg38
XM_011513422.2 chr4:g.1805818C>T c.1717C>T p.P573S RefSeq GRCh38/hg38
NM_001354810.2 chr4:g.1805818C>T c.1717C>T p.P573S RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FGFR3 P573S lung non-small cell carcinoma no benefit Fexagratinib Case Reports/Case Series Actionable In a Phase II trial (NLMT), AZD4547 treatment did not result in a confirmed response or durable clinical benefit in a patient with non-small cell lung cancer harboring FGFR3 P575S (corresponds to P573S in the canonical isoform (PMID: 32669708, NCT02664935). 32669708