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Gene FGFR3
Variant S371C
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions FGFR3 S371C lies within the extracellular domain of the Fgfr3 protein (UniProt.org). S371C confers a gain of function to the Fgfr3 protein as demonstrated by dimerization, constitutive activation, increased MAPK pathway signaling (PMID: 12009017), a growth advantage relative to wild-type Fgfr3 in a competition assay, and increased transformation activity in cultured cells (PMID: 34272467).
Associated Drug Resistance
Category Variants Paths

FGFR3 mutant FGFR3 act mut FGFR3 S371C

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Transcript NM_000142.5
gDNA chr4:g.1804365A>T
cDNA c.1111A>T
Protein p.S371C
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001354809.1 chr4:g.1804365A>T c.1111A>T p.S371C RefSeq GRCh38/hg38
XM_011513420.1 chr4:g.1804365A>T c.1111A>T p.S371C RefSeq GRCh38/hg38
XM_011513422 chr4:g.1804365A>T c.1111A>T p.S371C RefSeq GRCh38/hg38
XM_006713873 chr4:g.1804365A>T c.1111A>T p.S371C RefSeq GRCh38/hg38
NM_000142 chr4:g.1804365A>T c.1111A>T p.S371C RefSeq GRCh38/hg38
NM_001354810.1 chr4:g.1804365A>T c.1111A>T p.S371C RefSeq GRCh38/hg38
XM_011513422.1 chr4:g.1804365A>T c.1111A>T p.S371C RefSeq GRCh38/hg38
NM_001354810.2 chr4:g.1804365A>T c.1111A>T p.S371C RefSeq GRCh38/hg38
NM_000142.4 chr4:g.1804365A>T c.1111A>T p.S371C RefSeq GRCh38/hg38
XM_006713873.2 chr4:g.1804365A>T c.1111A>T p.S371C RefSeq GRCh38/hg38
XM_011513422.2 chr4:g.1804365A>T c.1111A>T p.S371C RefSeq GRCh38/hg38
NM_000142.5 chr4:g.1804365A>T c.1111A>T p.S371C RefSeq GRCh38/hg38
XM_011513420.2 chr4:g.1804365A>T c.1111A>T p.S371C RefSeq GRCh38/hg38
NM_001354809.2 chr4:g.1804365A>T c.1111A>T p.S371C RefSeq GRCh38/hg38
XM_006713873.1 chr4:g.1804365A>T c.1111A>T p.S371C RefSeq GRCh38/hg38
XM_006713872 chr4:g.1804365A>T c.1111A>T p.S371C RefSeq GRCh38/hg38
XM_011513420 chr4:g.1804365A>T c.1111A>T p.S371C RefSeq GRCh38/hg38
XM_047449824.1 chr4:g.1804365A>T c.1111A>T p.S371C RefSeq GRCh38/hg38
XM_047449822.1 chr4:g.1804365A>T c.1111A>T p.S371C RefSeq GRCh38/hg38
XM_047449823.1 chr4:g.1804365A>T c.1111A>T p.S371C RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FGFR3 S371C Advanced Solid Tumor predicted - sensitive Infigratinib Preclinical - Cell culture Actionable In a preclinical study, cells expressing FGFR3 S371C were sensitive to treatment with Truseltiq (infigratinib) in culture, demonstrating reduced cell viability (PMID: 34272467). 34272467
FGFR3 S371C Advanced Solid Tumor predicted - resistant Dovitinib Preclinical - Cell culture Actionable In a preclinical study, cells expressing FGFR3 S371C were resistant to treatment with Dovitinib (TKI258) in culture (PMID: 34272467). 34272467