FGFR2 M538L
Gene Variant Detail

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Gene FGFR2
Variant M538L
Impact List missense
Protein Effect unknown
Gene Variant Descriptions FGFR2 M538L lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). M538L has been identified as a secondary resistance mutation in the context of an FGFR2 fusion (PMID: 34250419), but has not been biochemically characterized and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Dec 2025).
Associated Drug Resistance
Category Variants Paths

FGFR2 mutant FGFR2 M538L

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Transcript NM_000141.5
gDNA chr10:g.121498555T>G
cDNA c.1612A>C
Protein p.M538L
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_006717710 chr10:g.121500835T>G c.1612A>C p.M538L RefSeq GRCh38/hg38
NM_001144913.1 chr10:g.121498558T>G c.1612A>C p.M538L RefSeq GRCh38/hg38
NM_001320658.2 chr10:g.121498549T>G c.1612A>C p.M538L RefSeq GRCh38/hg38
NM_001144913 chr10:g.121498558T>G c.1612A>C p.M538L RefSeq GRCh38/hg38
NM_001144913.1 chr10:g.121498558T>G c.1612A>C p.M538L RefSeq GRCh38/hg38
XM_006717710.4 chr10:g.121500835T>G c.1612A>C p.M538L RefSeq GRCh38/hg38
NM_022970.4 chr10:g.121498558T>G c.1612A>C p.M538L RefSeq GRCh38/hg38
NM_022970 chr10:g.121498558T>G c.1612A>C p.M538L RefSeq GRCh38/hg38
XM_006717710.5 chr10:g.121500835T>G c.1612A>C p.M538L RefSeq GRCh38/hg38
NM_000141.4 chr10:g.121498555T>G c.1612A>C p.M538L RefSeq GRCh38/hg38
NM_000141.5 chr10:g.121498555T>G c.1612A>C p.M538L RefSeq GRCh38/hg38
NM_000141 chr10:g.121498555T>G c.1612A>C p.M538L RefSeq GRCh38/hg38
NM_022970.3 chr10:g.121498558T>G c.1612A>C p.M538L RefSeq GRCh38/hg38
NM_001320658.1 chr10:g.121498549T>G c.1612A>C p.M538L RefSeq GRCh38/hg38
NM_001320658 chr10:g.121498549T>G c.1612A>C p.M538L RefSeq GRCh38/hg38

Filtering

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References