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Gene FGFR3
Variant E456K
Impact List missense
Protein Effect unknown
Gene Variant Descriptions FGFR3 E456K lies within the cytoplasmic domain of the Fgfr3 protein (UniProt.org). E456K has not been characterized in the scientific literature and therefore, its effect on Fgfr3 protein function is unknown (PubMed, Mar 2024).
Associated Drug Resistance
Category Variants Paths

FGFR3 mutant FGFR3 E456K

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Transcript NM_000142.5
gDNA chr4:g.1804923G>A
cDNA c.1366G>A
Protein p.E456K
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_006713873.1 chr4:g.1804923G>A c.1366G>A p.E456K RefSeq GRCh38/hg38
NM_000142.4 chr4:g.1804923G>A c.1366G>A p.E456K RefSeq GRCh38/hg38
XM_047449824.1 chr4:g.1804923G>A c.1366G>A p.E456K RefSeq GRCh38/hg38
NM_000142 chr4:g.1804923G>A c.1366G>A p.E456K RefSeq GRCh38/hg38
XM_006713873 chr4:g.1804923G>A c.1366G>A p.E456K RefSeq GRCh38/hg38
XM_006713873.2 chr4:g.1804923G>A c.1366G>A p.E456K RefSeq GRCh38/hg38
NM_000142.5 chr4:g.1804923G>A c.1366G>A p.E456K RefSeq GRCh38/hg38
XM_047449823.1 chr4:g.1804923G>A c.1366G>A p.E456K RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
FGFR3 E456K unknown