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Gene STK11
Variant R87K
Impact List missense
Protein Effect loss of function - predicted
Gene Variant Descriptions STK11 R87K lies within the protein kinase domain of the Stk11 protein (UniProt.org). R87K demonstrates kinase activity, subcellular localization, ability to inhibit proliferation, cell cycle progression, and colony formation similar to wild-type protein in cultured cells, and inhibits tumor growth in mouse models, but results in decreased protein stability, aberrant gene expression, failure to inhibit Fak phosphorylation, and leads to increased cell motility in cultured cells (PMID: 32647375), and therefore, is predicted to lead to a loss of Stk11 protein function.
Associated Drug Resistance
Category Variants Paths

STK11 mutant STK11 inact mut STK11 R87K

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Transcript NM_000455.5
gDNA chr19:g.1207173G>A
cDNA c.260G>A
Protein p.R87K
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000455.4 chr19:g.1207173G>A c.260G>A p.R87K RefSeq GRCh38/hg38
XM_005259617.3 chr19:g.1207173G>A c.260G>A p.R87K RefSeq GRCh38/hg38
NM_001407255.1 chr19:g.1207173G>A c.260G>A p.R87K RefSeq GRCh38/hg38
NM_000455 chr19:g.1207173G>A c.260G>A p.R87K RefSeq GRCh38/hg38
NM_000455.5 chr19:g.1207173G>A c.260G>A p.R87K RefSeq GRCh38/hg38
XM_005259617 chr19:g.1207173G>A c.260G>A p.R87K RefSeq GRCh38/hg38
XM_005259618 chr19:g.1207173G>A c.260G>A p.R87K RefSeq GRCh38/hg38
XM_005259618.3 chr19:g.1207173G>A c.260G>A p.R87K RefSeq GRCh38/hg38

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries