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HRAS A59T - Gene Variant Detail

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Gene HRAS
Variant A59T
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions HRAS A59T lies within the GTP binding domain of the Hras protein (UniProt.org). A59T does not affect Hras GTPase activity, but increases nucleotide exchange rate, resulting in increase GTP-bound Hras and transformation of cultured cells (PMID: 21779495, PMID: 3004741).
Associated Drug Resistance
Category Variants Paths

HRAS mutant HRAS act mut HRAS A59T

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Transcript NM_005343.4
gDNA chr11:g.533881C>T
cDNA c.175G>A
Protein p.A59T
Source Database RefSeq
Genome Build GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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  • Click on any column header arrows to sort by that column
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