Missing content? – Request curation!
Request curation for specific Genes, Variants, or PubMed publications.
Have questions, comments, or suggestions? - Let us know!
Email us at : ckbsupport@genomenon.com
Gene | HRAS |
Variant | A59T |
Impact List | missense |
Protein Effect | gain of function |
Gene Variant Descriptions | HRAS A59T lies within the GTP binding domain of the Hras protein (UniProt.org). A59T does not affect Hras GTPase activity, but increases nucleotide exchange rate, resulting in increase GTP-bound Hras and transformation of cultured cells (PMID: 21779495, PMID: 3004741). |
Associated Drug Resistance | |
Category Variants Paths |
HRAS mutant HRAS act mut HRAS A59T |
Transcript | NM_005343.4 |
gDNA | chr11:g.533881C>T |
cDNA | c.175G>A |
Protein | p.A59T |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |
Transcript | gDNA | cDNA | Protein | Source Database | Genome Build |
---|---|---|---|---|---|
NM_005343.4 | chr11:g.533881C>T | c.175G>A | p.A59T | RefSeq | GRCh38/hg38 |
NM_176795 | chr11:g.533881C>T | c.175G>A | p.A59T | RefSeq | GRCh38/hg38 |
NM_001130442 | chr11:g.533881C>T | c.175G>A | p.A59T | RefSeq | GRCh38/hg38 |
NM_005343.3 | chr11:g.533881C>T | c.175G>A | p.A59T | RefSeq | GRCh38/hg38 |
NM_001130442.3 | chr11:g.533881C>T | c.175G>A | p.A59T | RefSeq | GRCh38/hg38 |
NM_001130442.2 | chr11:g.533881C>T | c.175G>A | p.A59T | RefSeq | GRCh38/hg38 |
NM_176795.4 | chr11:g.533881C>T | c.175G>A | p.A59T | RefSeq | GRCh38/hg38 |
NM_005343 | chr11:g.533881C>T | c.175G>A | p.A59T | RefSeq | GRCh38/hg38 |
NM_176795.5 | chr11:g.533881C>T | c.175G>A | p.A59T | RefSeq | GRCh38/hg38 |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
HRAS A59T RET A883F RET A883T | medullary thyroid carcinoma | predicted - resistant | Pralsetinib | Case Reports/Case Series | Actionable | In a retrospective analysis, a medullary thyroid carcinoma patient harboring RET A883T progressed on treatment with Gavreto (pralsetinib) and was found to have acquired RET A883F and HRAS A59T (PMID: 38127829; NCT03157128, NCT03037385, NCT03780517). | 38127829 |