HRAS A59T - Gene Variant Detail

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Gene HRAS
Variant A59T
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions HRAS A59T lies within the GTP binding domain of the Hras protein (UniProt.org). A59T does not affect Hras GTPase activity, but increases nucleotide exchange rate, resulting in increase GTP-bound Hras and transformation of cultured cells (PMID: 21779495, PMID: 3004741).
Associated Drug Resistance
Category Variants Paths

HRAS mutant HRAS act mut HRAS A59T

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Transcript NM_005343.4
gDNA chr11:g.533881C>T
cDNA c.175G>A
Protein p.A59T
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_176795 chr11:g.533881C>T c.175G>A p.A59T RefSeq GRCh38/hg38
NM_176795.5 chr11:g.533881C>T c.175G>A p.A59T RefSeq GRCh38/hg38
NM_001130442.2 chr11:g.533881C>T c.175G>A p.A59T RefSeq GRCh38/hg38
NM_001130442 chr11:g.533881C>T c.175G>A p.A59T RefSeq GRCh38/hg38
NM_005343.3 chr11:g.533881C>T c.175G>A p.A59T RefSeq GRCh38/hg38
NM_005343.4 chr11:g.533881C>T c.175G>A p.A59T RefSeq GRCh38/hg38
NM_176795.4 chr11:g.533881C>T c.175G>A p.A59T RefSeq GRCh38/hg38
NM_005343 chr11:g.533881C>T c.175G>A p.A59T RefSeq GRCh38/hg38
NM_001130442.3 chr11:g.533881C>T c.175G>A p.A59T RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References