Gene Variant Detail

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Gene HRAS
Variant G12C
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions HRAS G12C does not lie within any known functional domains of the Hras protein (UniProt.org). G12C results in decreased Hras GTPase activity, loss of sensitivity to GTPase-activating proteins, thus leads to transformation of cells in culture (PMID: 24224811, PMID: 6092966).
Associated Drug Resistance
Category Variants Paths

HRAS mutant HRAS act mut HRAS G12C

HRAS mutant HRAS G12X HRAS G12C

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Transcript NM_005343.4
gDNA chr11:g.534289C>A
cDNA c.34G>T
Protein p.G12C
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_005343.4 chr11:g.534289C>A c.34G>T p.G12C RefSeq GRCh38/hg38
NM_001130442 chr11:g.534289C>A c.34G>T p.G12C RefSeq GRCh38/hg38
NM_176795 chr11:g.534289C>A c.34G>T p.G12C RefSeq GRCh38/hg38
NM_005343.3 chr11:g.534289C>A c.34G>T p.G12C RefSeq GRCh38/hg38
NM_176795.4 chr11:g.534289C>A c.34G>T p.G12C RefSeq GRCh38/hg38
NM_176795.5 chr11:g.534289C>A c.34G>T p.G12C RefSeq GRCh38/hg38
NM_001130442.2 chr11:g.534289C>A c.34G>T p.G12C RefSeq GRCh38/hg38
NM_005343 chr11:g.534289C>A c.34G>T p.G12C RefSeq GRCh38/hg38
NM_001130442.3 chr11:g.534289C>A c.34G>T p.G12C RefSeq GRCh38/hg38

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT05638698 Phase II Balstilimab + QS21 + TG01 QS21 + TG01 Tg01 Vaccine / Qs-21 Stimulon™ With Or Without Balstilimab As Maintenance Therapy Following Adjuvant Chemotherapy In Patients With Resected Pancreatic Cancer (TESLA) Active, not recruiting USA 0